15 The course of a progressive dementia such as Alzheimer disease will often distinguish it from impairment due to head injury or stroke. Notes This work was supported in part by National Institute of Mental Health grants MH43693, MH51459, MH45131, and MH49671, and by the

Department of Veterans Affairs. The first author was supported by 5 T32 MH19934-08.
Dementia has as its central feature impairment in cognitive function. Clinically, the cognitive deficit, will most often manifest selleck kinase inhibitor itself as memory problems and most. usually as difficulties in the ability Inhibitors,research,lifescience,medical to retain new information. However, a number of other areas of cognition are affected and it is important to realize that, memory is but one of the cognitive skills compromised in Inhibitors,research,lifescience,medical dementia. Dementia is thus prima facie a disorder of cognition and it is our cognitive facilities that underlie our abilities to engage successfully in the activities of daily living (ADL). From this it follows that enhancement to cognitive function will facilitate performance of these ADL. The assessment, and understanding of these impairments are crucial to any treatment of the Inhibitors,research,lifescience,medical disorder. Behavioral observation

today has a very limited role to play in the assessment of mental ability, as it is now known that many important aspects of cognitive function are not. readily assessable by this technique. Cognition can only truly be assessed accurately through the direct, use of objective psychometric tests. However, historically the diagnosis of dementia has been largely the province of gerontologists and old-age psychiatrists, who, in the absence of widely accepted tasks, relied primarily on their clinical judgment. Memory deficits Inhibitors,research,lifescience,medical are one of the more obvious aspects of cognitive disorder, both to the patient and the observer; therefore, the marked anterograde amnesia seen in Alzheimer’s and other dementias became the hallmark of the disorders. This legacy remains today and can be evidenced Inhibitors,research,lifescience,medical by inspecting the Diagnostic and Statistical Manual of Disorders, Fourth Edition (DSM-IV) guidelines for any of the dementias.1 Nonetheless, as will emerge

in this chapter, memory deficits are only one of several major aspects of cognitive dysfunction in dementia. Unfortunately, the principal instrument used in most of the major clinical trials of Alzheimer’s disease (AD) in recent years, the Alzheimer’s Disease Assessment Scale-Cognitive Subsection (ADAS-COG), primarily assesses aspects of 17-DMAG (Alvespimycin) HCl memory, which has resulted in other important cognitive deficits in dementia being overlooked. As a consequence, the full therapeutic potential of the treatments studied has not been evaluated. Assessment of cognitive function Cognitive functions are those aspects of mental activity that underpin the quality with which we are able to conduct ADL. A number of these aspects of mental activity are subject, to change in the efficiency with which they operate.