These functionally different iNKT subsets segregate

in th

These functionally different iNKT subsets segregate

in their ability to bind CD1d-tetramers loaded with the partial agonist alpha-linked glycolipid antigen OCH and structurally different endogenous beta-glycosylceramides. Using surface plasmon resonance with recombinant iNKT TCRs and different ligand-CD1d complexes, we demonstrate that the CDR3 beta sequence strongly impacts on the iNKT TCR affinity to CD1d, independent of the loaded AP26113 chemical structure CD1d ligand. Collectively our data reveal a crucial role for CDR3 beta for the function of human iNKT cells by tuning the overall affinity of the iNKT TCR to CD1d. This mechanism is relatively independent of the bound CD1d ligand and thus forms the basis of an inherent, CDR3 beta dependent functional hierarchy of human iNKT cells.”
“Genetic testing for BRCA1 and BRCA2 mutations is gaining acceptance LY2157299 concentration in clinical oncology worldwide and may help target unaffected high-risk women for prevention and for close surveillance. Annual screening with MRI seems to be an effective surveillance strategy, but the long term follow-up of women with small MRI-detected breast cancers is necessary to establish its ultimate value. Women with cancer and a BRCA mutation may benefit from

tailored treatments, such as cisplatin or olaparib. The treatment goals for a woman with a BRCA-associated breast cancer should be to prevent recurrence of the initial cancer and to prevent second primary breast and ovarian cancers. Mutations in BRCA1 and BRCA2 are presented throughout the world and it is important that the benefits of genetic testing and of targeted therapies be extended to women

who live outside of North America and Western Europe.”
“The viral haemorrhagic septicaemia virus (VHSV) comprises 4 major genotypes and a number of subtypes with, in most cases, distinct geographical distribution. A quick and simple detection method that can discriminate the different genotypes is desirable for a quick and more efficient prevention of the spread of genotypes to new geographical CX-6258 areas. A monoclonal antibody (MAb) against VHSV genotype IVa was produced, with the aim of providing a simple method of discriminating this genotype from the other VHSV genotypes (I, II, III and IVb). Balb/c mice were injected with purified VHSV-JF00Ehil (genotype IVa) from, diseased farmed Japanese flounder. Ten hybridoma clones secreting monoclonal antibodies (MAbs) against VHSV were established. One of these, MAb VHS-10, reacted only with genotype IVa in indirect fluorescent antibody technique (IFAT) and ELISA. Using cell cultures that were transfected with each of the viral protein genes, it was shown that the MAb VHS-10 recognizes a nonlinear genotype IVa-specific epitope on the VHSV N-protein.”
“Premise of research.

5 g kg(-1) body mass of CIT or placebo (PLC) in 1000 mL of soluti

5 g.kg(-1) body mass of CIT or placebo (PLC) in 1000 mL of solution. These trials were separated by 2 weeks. Baseline (before ingestion) aldosterone concentration did not differ between the 2 trials; however, it was 36.5% (p = 0.003) lower in the CIT trial compared with the PLC trial before the running test (i.e., after ingestion). The extent of the running-induced increase in

aldosterone was 33% (p = 0.009) smaller in the CIT trial. There were no between-trial differences in the levels of adrenocorticotropic hormone, BV-6 cell line N-terminal pro-B-type natriuretic peptide, or renin activity at any stage of the study. However, a greater relative increase in plasma volume (mean +/- SD, 6.41% +/- 3.78% vs. 4.08% +/- 3.33%; p = 0.042) was Wnt inhibitor observed after administering the CIT compared with the PLC drink. Serum Na(+) concentration increased (by 3.1 +/- 1.2 mmol.L(-1); p < 0.0001) after ingestion of the CIT but not the PLC drink. A higher Na(+) level was observed in the CIT trial than in the PLC trial (142.4 +/- 1.6 vs. 139.3 +/- 1.4 mmol.L(-1), p = 0.00001) after completion of the run. In conclusion,

pre-exercise ingestion of CIT induces a decrease in serum aldosterone concentration in the resting condition and a blunting of the aldosterone response during incremental running exercise to volitional exhaustion. The observed effect of CIT on the serum aldosterone level may be mediated by an acute increase in plasma volume and serum Na+ concentration alterations.”
“A 36-year-old woman presented to our hospital with a short history of intermittent headaches. All MRI of the brain

revealed a left temporal intracerebral cystic lesion with rim enhancement. Histopathology showed a malignant tumour With features of rhabdoid differentiation. Immunohistochemistry revealed that vimentin, epithelial membrane antigen and S-100 were positive, and that glial fibrillary acidic Protein and the chromosome deletion 1p/19q were negative. The patient was diagnosed as having an intracerebral cystic rhabdoid meningioma. She was treated With surgery and post-operative radiotherapy. Cystic intracerebral rhabdoid meningiomas are rare. We discuss the clinical picture of this patient with reference Ruboxistaurin to the published literature on this Uncommon diagnosis. (C) 2008 Elsevier Ltd. All rights reserved.”
“Sexually transmitted diseases (STD) are probably the most tabooed diseases we know. The many taboos and the related stigmata shape patients’ lives and significantly influence health care policies, medical research, and current problems in medical ethics. To better understand these complex influences, the still powerful taboos and related metaphors associated with illness and disease are analyzed within their cultural and historical background and concerning the actual impact on patient care and research.

6-7 6, and the influence of other differently charged proteins (a

6-7.6, and the influence of other differently charged proteins (apomyoglobin, egg lysozyme, lactalbumin, and BSA) has been studied at pH 7.4. It is shown that the rate of mitochondrial respiration in the presence of MbO(2) increases by 10-30% (V (1) > V (0)). No myoglobin effect is observed for FCCP-uncoupled MC (V (max) does not change). The rate of MbO(2) deoxygenation is equal to the rate of oxygen uptake by mitochondria (V (2)/V (1) similar to 1 at pH 7.2-7.5). At varying pH < 7.2, the V (2) values become markedly higher than V (1), evidently due Apoptosis inhibitor to

the increased MbO(2) positive charge and its stronger interaction with negatively charged mitochondrial membrane. At pH 7.4, on the contrary, V (2) is twice lower than V (1) in the case of negatively charged CM-MbO(2) (pI

5.2), which has carboxymethylated histidines. Positively charged lysozyme (pI 11) strongly inhibits MbO(2) deoxygenation (V (2)) without affecting oxygen uptake by MC (V (0) and V (1)). At the same time, apomyoglobin (pI 8.5), which is structurally very similar to the holoprotein, and both negatively charged lactalbumin (pI 4.4) and BSA (pI 4.7) have no substantial influence on V (2) and V (1). The MC membrane evidently has no specific sites for the interaction with myoglobin. Rather, the protein contacts with phospholipids of the outer membrane during MbO(2) deoxygenation, and electrostatic interactions are of great importance for this process.”
“A GSK J4 mw compelling example of auditory-visual multisensory integration AZD6738 manufacturer is the McGurk effect, in which an auditory syllable is perceived very differently depending on whether it is accompanied by a visual movie of a speaker pronouncing the same syllable or a different, incongruent syllable. Anatomical and physiological studies in human and nonhuman primates have suggested that the superior temporal sulcus (STS) is involved in auditory-visual integration for both speech and nonspeech stimuli.

We hypothesized that the STS plays a critical role in the creation of the McGurk percept. Because the location of multisensory integration in the STS varies from subject to subject, the location of auditory-visual speech processing in the STS was first identified in each subject with fMRI. Then, activity in this region of the STS was disrupted with single-pulse transcranial magnetic stimulation (TMS) as subjects rated their percept of Mc Gurkand non-McGurk stimuli. Across three experiments, TMS of the STS significantly reduced the likelihood of the McGurk percept but did not interfere with perception of non-McGurk stimuli. TMS of the STS was effective at disrupting the McGurk effect only in a narrow temporal window from 100 ms before auditory syllable onset to 100 ms after onset, and TMS of a control location did not influence perception of McGurk or control stimuli. These results demonstrate that the STS plays a critical role in the McGurk effect and auditory-visual integration of speech.

Results The C-13-MBT differed significantly between healthy

\n\nResults. The C-13-MBT differed significantly between healthy controls and cirrhotic patients at all time intervals measured. It also proved the ability to differentiate patients with liver cirrhosis based on severity of hepatic impairment corresponding to the Child-Pugh classification A vs. B vs. C. The ROC curve analysis suggested that the best prediction is provided by time intervals between the 10th – 20th

or 10th – 40th minute of PDR.\n\nConclusions. The C-13-MBT offers a reliable means for quantification of hepatic metabolic function over the complete range of functional liver impairment. It is non-invasive, easy to perform and completely safe.”
“PURPOSE CH5424802 purchase ACY-1215 research buy To describe optical coherence tomography (OCT) findings of ocular lesions in pseudoxanthoma elasticum (PXE).\n\nMETHODS. Sixteen eyes of 8 patients with PXE and 20 eyes of 10 age-matched healthy volunteers were included in the study. All patients in the study and control group underwent a complete ophthalmologic examination and OCT. Fluorescein angiography was performed on the patients with PXE.\n\nRESULTS. In the areas of peau de orange mottling, OCT demonstrated increased reflectivity on the level of retinal pigment epithelium (RPE), Bruch membrane, and choriocapillaris complex. OCT scans of crystalline

body showed a hyperreflective shell and an isoreflective or hyporeflective core. OCT scans of the angioid streaks demonstrated thinning in RPE-Bruch

membrane-choriocapillaris complex.\n\nCONCLUSIONS. Disturbances on the 4EGI-1 purchase level of RPE, choroid, and Bruch membrane may be responsible for the ocular lesions in PXE. OCT may give clues to the pathophysiology of the retinal lesions. Spectral domain OCT could provide more details and information. Further studies using this new technology should be performed. (Eur J Ophthalmol 2010; 20: 397-401)”
“Using a microfluidic chip, we have investigated whether bone marrow mesenchymal stem cells (BM-MSCs) could ameliorate IL-1 beta/IFN-gamma-induced dysfunction of INS-1 cells. BM-MSCs were obtained from diabetes mellitus patients and their cell surface antigen expression profiles were analyzed by flow cytometric. INS-1 cells were cocultured with BM-MSCs on a microfluidic chip with persistent perfusion of medium containing 1 ng/mL IL-1 beta and 2.5 U/mL IFN-gamma for 72 h. BM-MSCs could partially rescue INS-1 cells from cytokine-induced dysfunction and ameliorate the expression of insulin and PDX-1 gene in INS-1 cells. Thus BM-MSCs can be viewed as a promising stem cell source to depress inflammatory factor-induced dysfunction of pancreatic beta cells in diabetic patients.

0022), specialty care (p = 0 0141), diagnostic services (p < 0

0022), specialty care (p = 0.0141), diagnostic services (p < 0.0001), hospitalizations (p = 0.0069), and total charges (p < 0.0001). For female patients, the regression equation predicted 14% of the variation in total medical charges compared with 28% for males. Female patients had higher charges

for primary care (p = 0.0019), diagnostic see more services (p = 0.0005), and total charges (p = 0.0180).\n\nConclusions: Health status and patient gender were significant predictors of healthcare use and charges. The R(2) of total charges was two times higher for men vs. women. This research has policy implications for healthcare organizations in predicting the usage patterns.”
“This study was a randomized controlled trial to investigate

the effect of treating women with stress or mixed urinary incontinence (SUI or MUI) by diaphragmatic, deep abdominal and pelvic floor muscle (PFM) retraining. Seventy women were randomly allocated to the training (n = 35) or control group LDK378 cost (n = 35). Women in the training group received 8 individual clinical visits and followed a specific exercise program. Women in the control group performed self-monitored PFM exercises at home. The primary outcome measure was self-reported improvement. Secondary outcome measures were

20-min pad test, 3-day voiding diary, maximal vaginal squeeze pressure, holding time and quality of life. After a 4-month intervention period, more participants in the training group reported that they were cured or improved (p < 0.01). The cure/improved rate was above 90%. Both amount of leakage and number of leaks were significantly lower in the training group (p<0.05) but not in the control group. More aspects of quality of life improved significantly in the training group than in the control group. Maximal vaginal squeeze pressure, however, decreased CH5183284 slightly in both groups. Coordinated retraining diaphragmatic, deep abdominal and PFM function could improve symptoms and quality of life. It may be an alternative management for women with SUI or MUI. (C) 2010 Elsevier Ltd. All rights reserved.”
“This study investigated the effects of heme oxygenase 1 (HO-1) on thrombomodulin (TM) and endothelial protein C receptor (EPCR) expression in sepsis-induced kidney injury. The role of HO-1 was evaluated in a cecal ligation and puncture (CLP)-induced model. Wistar rats were randomly assigned into four groups: sham, CLP, CLP + hemin (an HO-1 inducer), CLP + ZnPP (zinc protoporphyrin IX, an HO-1 inhibitor), and CLP + bilirubin.

One immunosuppressive patient lost his life before initiation of

One immunosuppressive patient lost his life before initiation of treatment. With regard to disease progression, it was detected that two cases (of whom one was renal and one was bone marrow transplant patient) lost their lives

(mortality rate: 14%), however all the other cases were cured completely. The present study comprised the highest number of visceral leishmaniasis adult cases reported in Turkey and enabled the review of disease characteristics. In conclusion, cases presenting with fever, hepatosplenomegaly, pancytopenia and hypoalbuminemia check details and living in endemic regions should be precisely evaluated in terms of visceral leishmaniasis.”
“The C-3 plant Rhazya stricta is native to arid desert environment zones, where it experiences daily extremes of heat, light intensity (PAR) and high vapour pressure deficit (VPD). We measured the photosynthetic parameters

in R. stricta in its native environment to assess the mechanisms that permit it to survive in these extreme conditions. Infrared gas exchange MLN4924 in vitro analysis examined diel changes in assimilation (A), stomatal conductance (g(s)) and transpiration (E) on mature leaves of R. stricta. A/c(i) analysis was used to determine the effect of temperature on carboxylation capacity (V-c,V-max) and the light- and CO2-saturated rate of photosynthesis (A(max)). Combined chlorophyll fluorescence and gas exchange light response curve analysis at ambient and low oxygen showed that both carboxylation and oxygenation of Rubisco acted as the major sinks for the end products of electron transport. Physiological analysis in conjunction with gene expression analysis suggested that there are two isoforms of Rubisco activase which may provide an explanation for the ability of R. stricta to maintain Rubisco function at high temperatures. The potential to exploit

this ability to cope with extreme temperatures is discussed in the context of future crop improvement.”
“Diseases of the respiratory TGF-beta cancer tract are among the leading causes of death in the world population. Increasing evidence points to a key role of the innate immune system with its pattern recognition receptors (PRRs) in both infectious and noninfectious lung diseases, which include pneumonia, chronic obstructive pulmonary disease, acute lung injury, pneumoconioses, and asthma. PRRs are capable of sensing different microbes as well as endogenous molecules that are released after cell damage. This PRR engagement is the prerequisite for the initiation of immune responses to infections and tissue injuries which can be beneficial or detrimental to the host. PRRs include the Toll-like receptors, NOD-like receptors, RIG-I like receptors, and cytosolic DNA sensors. The PRRs and their signaling pathways represent promising targets for prophylactic and therapeutic interventions in various lung diseases.

Since Stat3 initiates its signaling activity through binding of i

Since Stat3 initiates its signaling activity through binding of its SH2 domain to phosphotyrosine see more residues on cell surface receptors, inhibitors targeting this region of the protein are potential chemotherapeutic agents. To date, no NMR or X-ray crystallographic structures of high-affinity phosphopeptides complexed with the Stat3 SH2 domain are available to aid in the development of peptidomimetic antagonists. Examination of the crystal structures of several STAT proteins and the complex of Stat1 with Ac-pTyr-Asp-Lys-Pro-His-NH2 led to

a hypothesis that the specificity determinant for Stat3, glutamine at position pY+3 in pTyr-Xxx-Xxx-Gln sequences, resides in a unique pocket on the protein surface at the juncture of the third strand of the central beta-sheet and a unique, STAT specific alpha-helix. Docking of Ac-pTyr-Leu-Pro-Gln-NHBn to the SH2 domain of Stat3 using molecular modeling showed that the Gln binds tightly in this pocket and Ricolinostat order participates in a network of hydrogen bonds. Novel interactions between the peptide main chain and the protein were

also discovered. Phosphopeptide structure-affinity studies using unnatural amino acids and glutamine derivatives provide evidence for the peptide-protein interactions revealed by the model and lend support to the binding hypothesis. (C) 2007 Wiley Periodicals, Inc.”
“The key visual VX-770 purchase G protein, transducin undergoes bi-directional translocations between the outer segment (OS) and inner compartments of rod photoreceptors in a light-dependent manner thereby contributing to adaptation and neuroprotection of rods. A mammalian uncoordinated 119 protein (UNC119), also known as Retina Gene 4 protein (RG4), has been recently implicated in transducin transport to the OS in the dark through its interaction with the N-acylated GTP-bound transducin-alpha subunit (G alpha(t1)).

Here, we demonstrate that the interaction of human UNC119 (HRG4) with transducin is dependent on the N-acylation, but does not require the GTP-bound form of G alpha(t1). The lipid specificity of UNC119 is unique: UNC119 bound the myristoylated N terminus of G alpha(t1) with much higher affinity than a prenylated substrate, whereas the homologous prenyl-binding protein PrBP/delta did not interact with the myristoylated peptide. UNC119 was capable of interacting with G alpha(t1) GDP as well as with heterotrimeric transducin (G(t)). This interaction of UNC119 with G(t) led to displacement of G beta(1)gamma(1) from the heterotrimer. Furthermore, UNC119 facilitated solubilization of G(t) from dark-adapted rod OS membranes. Consistent with these observations, UNC119 inhibited rhodopsin-dependent activation of G(t), but had no effect on the GTP-hydrolysis by G alpha(t1).

Methods: lmmunohistochemistry and Western blot were used to s

\n\nMethods: lmmunohistochemistry and Western blot were used to study MUC1 expression pattern AZD5582 mw and localization in mitochondria. Coimmunoprecipitation was used to study MUC1 interaction with HSP70. MUC1 expression was correlated with other causative features including erbB2 expression.\n\nResults: MUC1 was expressed in 75.8% (147/194). MUC1 overexpression was detected in 50.0% (19/38 cases) dysplasia and 58.2% (32/55 cases) adenocarcinoma tissues. MUC1-CT-HSP70 interaction was seen in 71.66% (43/60 cases) and MUC1 localized to mitochondria in 33.33% (5/15) dysplasia samples and in 47.05% (8/17) adenocarcinoma samples. MUC1 expression showed significant association

with smoking (chi(2)=5.945; p<0.015), alcohol consumption (chi(2)=4.055; p<0.044) and erbB2 positivity (chi(2)=10.75; p<0.001). MUC1 expression did not show appreciable association with age (chi(2)=0.15; p<0.698), sex (chi(2)=0.22; p<0.640) or Helicobacter pylori infection (chi(2)=3.06; p<0.080).\n\nConclusions: Significant correlation was found between MUC1 expression and smoking, alcohol and erbB2 expression. MUC1 showed aberrant expression in dysplasia and adenocarcinoma stages. MUC1 cytosolic tail was bound by HSP70 in all the stages but MUC1-CT was found to localize in mitochondria

only in dysplasia and adenocarcinoma. MUC1-CT localization to mitochondria in dysplasia and adenocarcinoma might aid in the attenuation of epithelial stress response induced loss of polarity. (C) 2010 Elsevier B.V. All rights reserved.”
“Dendritic cells (DCs) function Small molecule library cost by stimulating naive antigen-specific CD4 T cells to proliferate and see more secrete a variety of immunomodulatory factors. The ability to activate naive T cells comes from the capacity of DCs to internalize, degrade, and express peptide fragments of antigenic proteins on their surface bound to MHC class II molecules (MHC-II). Although DCs express tens of thousands of distinct MHC-II, very small amounts of specific peptide-MHC-II complexes are required to interact with and activate T cells. We now show that stimulatory MHC-II

I-Ak-HEL(46-61) complexes that move from intracellular antigen-processing compartments to the plasma membrane are not randomly distributed on the DC surface. Confocal immunofluorescence microscopy and quantitative immunoelectron microscopy reveal that the majority of newly generated MHC-II I-Ak-HEL(46-61) complexes are expressed in sub-100-nm microclusters on the DC membrane. These microclusters are stabilized in cholesterol-containing microdomains, and cholesterol depletion inhibits the stability of these clusters as well as the ability of the DCs to function as antigen-presenting cells. These results demonstrate that specific cohorts of peptide-MHC-II complexes expressed on the DC surface are present in cholesterol-dependent microclusters and that cluster integrity is important for antigen-specific naive CD4 T cell activation by DCs.

48xC(0 4261)x(1-e(-0 2021t)) x100%, an equation that can be used

48xC(0.4261)x(1-e(-0.2021t)) x100%, an equation that can be used to predict the reducing sugar yield in an enzymolysis process. The RSY by enzymatic FDA-approved Drug Library ic50 loading of 35FPU/g achieved almost the highest yield after 48 h, and there was no significant improvement with further extension of the enzymolysis time. The modeling was validated within the enzymatic loading range of 15 to 35FPU/g and provided a satisfactory interpretation of the experimental data.”
“Fifty-four Caucasian parsley frogs, Pelodytes caucasicus, from Turkey were examined for helminths in 2005. Found were 1 species of Digenea, Gorgodera cygnoides; 5 species of Nematoda, Agfa tauricus, Aplectana

brumpti, Cosmocerea ornata, Oswaldocruzia filifiormis, Belnacasan and Rhabdias bufonis: and 1 species of Acanthocephala, Pseudoacanthocephala caucasicus. Pelodytes caucasicus represents a new host record for each of the parasite species; Agfa tauricas and Pseudoacanthocephala caucasicus are reported from Turkey for the first time.”
“Background: Specific morphologic features of hepatocellular carcinoma (HCC) on imaging have identifiable pathologic correlates as well as implications for altering surgical management and defining prognosis.

In this study, we compared susceptibility-weighted imaging (SWI) to conventional techniques and correlated our findings with histopathology to determine the role of SWI in assessing morphologic features of HCC without using a contrast agent. Methods: 86 consecutive patients with suspected HCC were imaged with MRI (including T1, T2, T2*, and SWI) and subsequently CT. 59 histologically-proven HCC lesions were identified in 53 patients. Each lesion on each imaging sequence was evaluated by two radiologists, and classified with respect to lesion morphology, signal intensity relative to surrounding hepatic parenchyma, presence of a pseudocapsule, presence of venous invasion, and internal homogeneity. Results: Histopathology confirmed pseudocapsules in 41/59 lesions. SWI was able to detect a pseudocapsule in 34/41 lesions; compared to conventional T1/T2 imaging

(12/41) and T2* (27/41). Mosaic pattern was identified in 25/59 lesions by histopathology; SWI confirmed this in all 25 lesions, compared to T1/T2 imaging (13/25) or T2* (18/25). Hemorrhage was confirmed by histopathology in 43/59 lesions, and visible MK-0518 supplier on SWI in 41/43 lesions, compared to T1/T2 (7/43) and T2* (38/43). Venous invasion was confirmed by histopathology in 31/59 patients; SWI demonstrated invasion in 28/31 patients, compared to T1/T2 (7/31) and T2* (24/31). Conclusions: SWI is better at identifying certain morphologic features such as pseudocapsule and hemorrhage than conventional MRI without using a contrast agent in HCC patients.”
“Bones are structures that give the shape and defined features to vertebrates, protect several soft organs and perform multiple endocrine influences on other organs.

Glucose tolerance was only impaired in adult males CD-fed adult

Glucose tolerance was only impaired in adult males. CD-fed adult males

showed fewer entries into the aversive open arms and groomed more on the EPM, whereas adult females spent more time on these arms. In the OF, CD-fed females of both ages visited the inner zone more frequently and travelled a longer distance. The behavioural data suggests anxiolysis in CD-fed females and signs of increased anxiety in adult males. In conclusion, this study demonstrates that feeding CD leads to both obesity and behavioural changes in rats. Overall, these effects were more pronounced in older rats, with the behavioural effects being particularly gender dependent. (C) 2013 Elsevier Inc. All rights reserved.”
“Aim. – To describe drugs used in the non-hormonal treatment of metastatic prostate cancer. Material. – Bibliographical search was performed from the database Medline (National Sapitinib Library of Medicine, PubMed) and websites of the HAS and the ANSM. The search was focused on the characteristics,

the mode of action, the efficiency and the side effects of the various drugs concerned. Results. – The metabolic radiotherapy although under-used for this indication, kept a place at the beginning of the disease. Radium-223 chloride seems to have to occupy an important place in the coming years. The chemotherapy, the only recourse until very recently in the castration-resistant prostate cancer, must YAP-TEAD Inhibitor 1 mw redefine its place partially. The denosumab provide an interesting alternative to bisphosphonates. Conclusion. – The non-hormonal treatment of the metastatic disease Navitoclax mouse of the prostate cancer is changing rapidly with the emergence of new molecules. Urologist must know perfectly these new drugs. (C) 2013 Elsevier Masson SAS. All rights reserved.”
“PURPOSE. To compare the changes in iris volume with pupil dilation using anterior segment optical coherence tomography (AS-OCT) in eyes of subjects with different subtypes

of primary angle closure.\n\nMETHODS. This prospective study examined 44 fellow eyes (FA group) of subjects with previous acute primary angle closure (APAC), and 56 subjects (AC group) with chronic primary angle closure and/or primary angle closure glaucoma. All participants underwent gonioscopy and AS-OCT imaging. The iris volume, iris cross-sectional area, and pupil diameter were measured with custom semiautomated software. The main outcome variable analyzed was mean change in iris volume between light and dark conditions in a multivariate linear regression analysis.\n\nRESULTS. Thirty-five eyes from the FA group (79.5%) and 50 eyes from the AC group (89.3%) were included in the final analysis. When going from light to dark, iris volume did not change significantly in eyes in the FA group (+/- 1.50 +/- 6.73 mm(3); P = 0.19), but decreased in the AC group by 1.52 +/- 3.07 mm(3) (P < 0.001). This difference was significant (P = 0.01).