The age distribution of reported pertussis cases and estimated incidence of infection reveal a similar, GS-1101 order however, not identical age-related trend, both showing peaks in adolescence. However, the highest incidence of notified cases is observed in children aged 10–14 years followed by a steady decrease with age, while the estimated rate of infection peaks twice, among 15–19-year old subjects as well as in the older age cohort (>60 years). Similar age-profiles have been observed in other developed countries such as Australia, Finland, and France in the pre-booster era [14] and [22]. Yet, these age-specific incidence patterns of B.

pertussis infections clearly reflect the dynamics of immunity and transmission in the populations. While high peaks of incidence rates among adolescents and young adults might indicate high rates of transmission, low rates of infection may be related to less contact and exposure as observed for the group of 40–59-year olds. Our findings are supported by a small pertussis outbreak among Israeli soldiers reported during the study period, in winter 2001, suggesting a high rate of exposure in young adults during their army service [23]. According to a previous survey, about 13% of Israeli military recruits who were seronegative for pertussis at time of enrolment, have shown seroconversion during their 3-year military service [24]. In addition, the present

data revealed that the levels of serologically defined infection were higher in the Israeli Arab population and groups of lower socio-economic status, which may be MAPK inhibitor explained by higher person-to-person transmission of B. pertussis

due to more crowding in these cohorts. In younger age groups (<9 years), both, the reported as well the estimated incidence data reveal considerable pertussis activity, suggesting that susceptibility for symptomatic infection in some individuals Tryptophan synthase may re-emerge even short time after primary pertussis vaccination [25]. Indeed, the finding of widespread circulation of B. pertussis may have several reasons. One is low vaccination coverage as observed in countries such as Italy or Germany [15], moreover, primary vaccination failure due to inadequate vaccination schedules, types of vaccines, or waning immunity after primary vaccination. The latter may most likely explain the recently observed resurgence in highly vaccinated populations like Israel. However, the present study also provides evidence of waning protection following natural infection, as there was a high rate of seropositivity and infections occurring in the population older than 60 years old age; a group which most likely have acquired natural immunity during their lives. Limited existing data on this topic suggest that pertussis vaccinated persons become susceptible to pertussis disease 5–10 years following the primary vaccination series, while immunity after natural infection seems to be lost after 10–20 years [26], [27] and [28].