37 ± 0.04, significantly lower than all other graphs) across thresholds, and the variable structure of the voxelwise graph is reflected in NMI that ranges widely over Obeticholic Acid purchase thresholds (0.58–0.86), in contrast to the stable

and high NMI found in the areal (0.72 ± 0.06) and modified voxelwise graphs (0.87 ± 0.15). Importantly, as thresholds rise, NMI between functional systems and subgraphs increases for the modified voxelwise analysis, but decreases for the standard voxelwise analysis. The areal and modified voxelwise graphs best meet our predictions about the correspondence between functional systems and subgraphs within brain-wide networks. The poorer correspondence in the AAL-based and standard voxelwise graphs likely results from coarse, nonfunctionally based nodes in the AAL-based graph, and the effects of millions of artificially high short-range correlations between nearby voxels in the standard voxelwise graph. We turn now from our focus upon confirmatory findings to novel observations Everolimus price about functional brain organization that can be drawn from the areal and modified voxelwise graphs. We shall continue to focus on the network at the level of subgraphs. We begin by discussing the identities of subgraphs, then examine

the relationships and properties of particular subgraphs, and end with observations about relationships between all subgraphs. The identities of the red (default), yellow (fronto-parietal task control), green (dorsal attention), and teal (ventral attention)

subgraphs are already clear. The remaining major subgraphs are now considered. Several subgraphs correspond to sensory and motor regions (Figure 4, left). A visual system (blue) was identified, spanning most of occipital cortex, often including a small portion of superior parietal cortex for and a portion of the postero-lateral thalamus (potentially lateral geniculate nucleus [LGN], see horizontal sections). At moderate thresholds, somatosensory-motor (SSM) cortex (S1, M1, and some pre- and postcentral-gyrus cortex) was divided into dorsal (cyan) and ventral (orange) subgraphs. These subgraphs also included voxels in the parietal operculum that likely correspond to the second somatosensory area (S2) (Burton et al., 2008), as well as a portion of the thalamus possibly corresponding to ventral posterior thalamus (VP). At high thresholds, an auditory subgraph (pink) emerged from the purple cingulo-opercular subgraph. Rather than a division between somatosensory and motor regions, a division between dorsal and ventral SSM regions is found.