In elderly patients and in patients with underlying cardiovascular disease and other risk factors for thrombosis, these agents should be used, when strictly indicated. Anamnestic response with the increase in FVIII inhibitor after APCC treatment has been reported only in the haemophilic patients [14]. Data on the use of FVIII replacement therapy in acquired haemophilia are scanty. Its use should be attempted only in case of low inhibitor

titre (<5 BU mL), minor bleeding and no bypassing agents availability. According to the experience in congenital haemophilia with alloantibodies, a loading dose should be given as bolus to neutralize the inhibitor and to achieve the haemostatic level, followed by subsequent doses given by bolus or by continuous infusion for maintenance [15]. The www.selleckchem.com/products/Nolvadex.html recovery and half-life of the infused this website FVIII:C cannot be predicted because of the variable kinetics of FVIII:C. In case of no satisfactory response within 24–48 h, one should resort to a by-passing agent. Desmopressin, a synthetic vasopressin analogue, releases FVIII/von Willebrand factor from the vascular endothelium. Its use in acquired haemophilia is

anecdotal; the indications are the same as for FVIII concentrates [16]. When infused intravenously or administered subcutaneously or intranasally, FVIII:C increases three- to five-fold above the baseline and reach a value sufficient to treat minor bleeding. The tachyphylaxis phenomenon limits it use to 3 or 4 上海皓元 consecutive days. The antidiuretic and vasomotor side-effects require caution in older patients. The response to high-dose immunoglobulins has been attributed to the presence of anti-idiotype antibodies in the pooled immunoglobulins, but at present, there is no evidence for its use as a single agent in acquired haemophilia [17]. A possible application is as an integral component of immune tolerance induction protocol [18–20]. The aim of the immunosuppressive therapy is the eradication of the inhibitor. Spontaneous complete remission (e.g. children, post-partum, drug-associated cases) were reported up to 36% of the patients [21], but are unpredictable and the

patients remain at great risk of severe bleeding if the inhibitor persists [1,22,23]. Therefore, immunosuppressive therapy should be initiated as soon as the diagnosis is established. No prospective, controlled studies evaluating the efficacy of the different therapeutic agents have been published. Prednisone as monotherapy or in combination with cyclophosphamide and azothioprin is the standard intervention [1,24] (Table 3). The therapy should be carried out with adequate doses and duration: previous experience in haemophiliacs points to the importance of carrying out the treatment according to haematological tolerance [25]. Complete remission rate is higher and overall mortality is lower in the treated patients. Response rate with prednisone alone is high, but a sustained remission after prednisone discontinuation is rare.