, 2010), and may reflect the intense processing of all Toolmaking stimuli by highly motivated Trained subjects. Activations exclusive to Expert subjects were observed in the medial frontal cortex, anterior intraparietal sulcus and inferior parietal lobule of the right hemisphere (Fig. 4, right). The medial frontal cortex is a core element in the network of brain

regions associated with the attribution of mental states (Frith & Frith, 2006), suggesting that Expert subjects rely on top-down interpretation of the demonstrator’s intentions in order to differentiate Acheulean from Oldowan toolmaking. The activation is centred at the border

http://www.selleckchem.com/products/bmn-673.html between a posterior region associated with the attribution of ‘private’ action intentions and an anterior region associated with communicative intentions (Grèzes et al., 2004a,b; Amodio & Frith, 2006), in a position closely approximating that activated when mentalizing about the internal states of a dissimilar other (Mitchell et al., 2006). It may reflect inference about the private technological ‘prior intentions’ of the demonstrator (Chaminade et al., 2002), rather than meta-cognition Roxadustat in vivo about the demonstrator’s communicative intentions toward the observer (Amodio & Frith, 2006: 274). Activation of the right anterior intraparietal sulcus in Experts is comparable to expertise effects found in studies of dance observation Hydroxychloroquine (Calvo-Merino et al., 2005, 2006; Cross et al., 2006). The more

anterior location the current activation may reflect somatotopy of response to the observation of upper vs. lower limb actions (Buccino et al., 2001). This particular region of right anterior intraparietal sulcus has also been linked with the preparation of successive sensorimotor task-sets during action sequence execution (Jubault et al., 2007). Also activated in Experts was a region of right inferior parietal lobule known to support the stimulus-driven allocation of spatial attention (Corbetta & Shulman, 2002; Mort et al., 2003) during visuospatial sequence learning (Rosenthal et al., 2009). This activation is posterior to the region associated with action outcome monitoring by Hamilton & Grafton (2008), and together with the right anterior intraparietal sulcus activation probably reflects Expert recognition of familiar toolmaking action sequences. Contrasts with Control show that the observation of Paleolithic toolmaking recruits cognitive control mechanisms in the pars triangularis of the right inferior frontal gyrus, and that this response increases with the technological complexity of the observed actions.