(2014) in their recent systematic review found that community-wide interventions reported a positive effect on children’s weight status.

It is therefore recommended that MDV3100 mouse any commissioning decisions to target specific schools for obesity prevention need to be based on robust data and, as is increasingly being recognised, consideration needs to be given to how any obesity prevention interventions will affect the wider environment and extend beyond the school gates. The authors declare that there are no conflicts of interest We thank the reviewers for their constructive comments. The authors would like to thank the staff of Devon County Council (including the former NHS Devon) for their advice throughout the project and for supplying the data. In particular we

thank Dr Virginia Pearson, Ian Tearle, Jane Batten, Teresa Lawless, Steve Kibble and Lucy O’Loughlin. AJW is funded by a Medical Research Council Doctoral Training Grant (MRC DTG PCMD/GS002) and Sport and Health Sciences, University of Exeter. SL, KMW, and WEH are partially supported by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Alectinib concentration Health Research and Care (CLAHRC) for the South West Peninsula. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health in England. “
“Colorectal cancer (CRC) is a leading cause of global cancer burden among men and women (Ferlay et al., 2010). In the United Kingdom (UK), CRC is the third most common incident cancer and cause of cancer death, from with over 40,000 new cases and over 15,000 deaths in 2010 (Cancer Research UK, 2013). England is one of the first countries worldwide to implement a national, organised, publicly available screening

programme using the faecal occult blood test (FOBT). The screening programme, entitled the National Bowel Cancer Screening Programme, is operated through the National Health Service (NHS) and was fully implemented in 2010. All adults aged 60–69 (currently being extended to 74) are eligible and receive a written screening invitation through the post with screening information and the home-based FOBT kit biennially beginning in the year of the 60th or 61st birthday. Although the FOBT reduces mortality (Hewitson et al., 2008 and Mandel et al., 1993), overall uptake of screening in England is low and substantially socially graded. An analysis of the first 2.6 million invitations to the programme from 2006 to 09 found that overall uptake was 54%, but was substantially lower among men and among adults living in deprived and ethnically diverse neighbourhoods (von Wagner et al., 2011). A further source of inequality in CRC screening participation in England may be low health literacy. Health literacy is defined as an individual’s capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions (Institute of Medicine, 2004).