8), ulnar (3.3), peroneal (4.6). The www.selleckchem.com/products/jq1.html results of the conduction studies were used to determine LNF impairment and classified, as follows: (1) normal; (2) axonal lesion, defined by a reduction of Compound Muscle Action Potentials (CMAP) and/or Sensory Nerve Action Potentials (SNAP), the amplitude being less than 30% of reference values and the sensory and/or MVC above 70% of reference value; (3) demyelination lesion, defined when the CMAP and/or SNAP latency prolonged compared to the reference value together with a

reduction of sensory and/or MCV below 85% of reference value; (4) mixed Inhibitors,research,lifescience,medical lesion, whenever there were both axonal and demyelinating lesions in the same nerve; and (5) no conduction. Abnormal temporal dispersion was defined as a proximal distal compound muscle action potential duration increase of more than 30% (Olney et al. 2003). Data were analyzed via SPSS™ 11.5 for Windows. The χ2, the Fisher’s Inhibitors,research,lifescience,medical exact, and the Mann–Whitney U tests were utilized to compare

PB and MB patient variables. The first and second exams were compared by the McNemar test; and P values under 0.05 were considered significant. Results Ten (45%) patients received the PB scheme (according to type of leprosy: one indeterminate, one Inhibitors,research,lifescience,medical tuberculoid, and eight borderline tuberculoid); and 12 (55%) received the MB scheme (four borderline lepromatous and eight lepromatous). Before treatment, most of the MB patients (92%) had a high (≥3.0) baciloscopic index. While 90% of all MB patients were male, only 50% of PB patients were (P= 0.056). A majority of the PB (90%) and MB (58%) patients had no observable disability at diagnosis according to grade of disability, but 73% of the 22 patients had NFI. Inhibitors,research,lifescience,medical All of the clinical parameters showed a nonsignificant higher percentage of alteration in MB as compared to PB patients (Table 1). While eight (36%) of the 22 patients (five MB) had nerve enlargement, none complained of nerve tenderness and were thus not diagnosed with acute neuritis. All patients (n= 12) who had at least one sensory nerve impairment Inhibitors,research,lifescience,medical had thermal and/or pain impairment, six of whom had tactile impairment as

well. Table 1 Neuropathy evaluation in paucibacillary (PB) and multibacillary (MB) patients: comparison between PB (n= 10) and MB (n= 12) patients (*P value of Fisher’s exact test), at diagnosis and follow-up (**P value of McNemar test). Eight patients Thiamine-diphosphate kinase (36%) had altered SVMR, seven on the ulnar topography (85% bilaterally), and five on the median topography (40% bilaterally). SSR was absent in eight (36%) of the patients. MB patients evidenced more frequent impairments on both tests, but only SVMR (Table 2) was significantly more altered in MB than PB patients (χ2= 5.5, P= 0.019). Interestingly, an association of the SVMR with the SNF clinical examination was observed in this sample of patients. Of the four patients with SNF clinical impairment, all had SVMR dysfunction (χ2= 8.556, P= 0.010).