Materials and Methods: Men in the SEARCH (Shared Equal
Access Regional Cancer Hospital) database who underwent radical prostatectomy between 1988 and 2010 after a known number of prior biopsies were included in the analysis. Number of biopsy sessions (range 1 to 8) was examined as a continuous and categorical (1, 2 and 3 to 8) variable. Biochemical recurrence was defined as a prostate specific antigen greater than 0.2 ng/ml, 2 values at 0.2 ng/ml or secondary treatment for an increased prostate specific antigen. The association between number of prior biopsy sessions selleck chemicals llc and biochemical recurrence was analyzed using the Cox proportional hazards model. Kaplan-Meier estimates of freedom from biochemical recurrence were compared among the groups.
Results:
Of the 2,739 men in the SEARCH database who met the inclusion criteria 2,251 (82%) had only 1 biopsy, 365(13%) had 2 biopsies and 123 (5%) had 3 or more biopsies. More biopsy sessions were associated with higher prostate specific antigen (p < 0.001), greater prostate weight (p < 0.001), lower biopsy Gleason sum (p = 0.01) and more organ confined (pT2) disease (p = 0.017). The Cox proportional hazards model demonstrated no association between number Capmatinib in vitro of biopsy sessions as a continuous or categorical variable and biochemical recurrence. Kaplan-Meier estimates of freedom from biochemical recurrence were similar across biopsy groups (log rank p = 0.211).
Conclusions: Multiple biopsy sessions these are not associated with an increased risk of biochemical recurrence in men undergoing
radical prostatectomy. Multiple biopsy sessions appear to select for a low risk cohort.”
“The purpose of this paper is to study the mechanism of apparent diffusion coefficient reduction after stroke by using multi b value diffusion-weighted imaging.
Ten healthy people and 25 patients with acute stroke were enrolled. In healthy volunteers, region of interests were put in the semioval center and in the precentral gyrus. In patients with acute stroke, region of interests were put in lesions and contralateral normal brain regions. ADC(fast) and ADC(slow) are thought of as a fast and a slow apparent diffusion coefficient, which result from the extracellular and intracellular compartments, respectively. p (fast) and p (slow) are regarded as the percentage of signal intensities deriving from water diffusion of the extracellular and intracellular compartments, separately. All data were analyzed using paired, two-tailed t tests. Statistical analyses were performed using SPSS 15.0.
In patients with acute stroke, p (fast) in lesions (0.54 +/- 0.11) is lower than that in normal regions (0.75 +/- 0.09), while p (slow) is on the contrary. ADC(fast) and ADC(slow) values in lesions are less than those in normal areas.