Among non-manual workers, there was an inverse linear relationship between educational level and AMI risk independent of CVRFs: compared with university educated individuals, the odds ratio (OR) for an AMI among those with a high school education was 1.63 (95% confidence interval [CI], 1.16-2.3), and among those with an elementary school education, 3.88 (95% CI, 2.79-5.39). No association between educational level and AMI risk was observed in manual workers. However, the AMI risk was higher in manual workers than non-manual university educated workers: in those with an elementary school education, the increased risk (OR=2.09; 95% CI, 1.59-2.75) was independent of CVRFs.
Conclusions. An association Panobinostat order was found
between socioeconomic status and AMI risk. The AMP risk was greatest in individuals with only an elementary school education, irrespective of CVRFs and social class, as indicated by occupation.”
“Background: The New Zealand population has both marginal selenium status and mild iodine deficiency. Adequate intakes of iodine and selenium are required for optimal thyroid function.
Objective: The aim of the study was to determine whether low selenium and iodine status compromises thyroid function in an older
New Zealand population.
Design: We investigated the effects of selenium HSP990 clinical trial and iodine supplementation in a double-blind, randomized, placebo-controlled trial in 100 Dunedin volunteers aged 60-80 y. Participants received 100 mu g Se/d as L-selenomethionine, 80 mu g I, 100 mu g Se + 80 mu g I, or placebo for 3 mo. Thyroid-stimulating hormone (TSH), free triiodothyronine (T-3), free thyroxine (T-4), thyroglobulin, plasma selenium, whole-blood
glutathione peroxidase (GPx) activity, and urinary iodine concentrations (UICs) were measured.
Results: Plasma selenium (P < 0.0001) and whole-blood GPx activity (P, 0.0001) increased from baseline to week 12 in the selenium and selenium plus iodine groups in comparison with the placebo group. Median UIC at baseline was 48 mu g/L (interquartile range: 31-79 mu g/L), which is indicative of moderate iodine deficiency. UIC increased AC220 in the iodine and selenium plus iodine groups and was significant only for the iodine group (P = 0.0014). Thyroglobulin concentration decreased by 24% and 13% of baseline in the iodine and selenium plus iodine groups in comparison with the placebo group (P = 0.009 and P = 0.108, respectively). No significant treatment effects were found for TSH, free T-3, free T-4, or ratio of T-3 to T-4.
Conclusions: Additional selenium improved GPx activity but not the thyroid hormone status of older New Zealanders. Iodine supplementation alleviated the moderate iodine deficiency and reduced elevated thyroglobulin concentrations. No synergistic action of selenium and iodine was observed. The trial was registered at www. anzctr.org.au/registry/as ACTRN012605000368639. Am J Clin Nutr 2009;90:1038-46.