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“Background Increasing proportions of patients diagnosed with cancer will become long-term survivors (=5?years post-diagnosis). However, survivors may continue to experience negative effects of cancer and/or treatment, including fear of recurrence (FoR). This review aims to provide an

overview of current knowledge on FoR, including determinants and consequences in long-term cancer survivors, and to outline methodological and conceptual challenges that should be addressed in future research. Methods Multiple databases including PUBMED, EMBASE, and PsycINFO were searched to identify relevant articles. Seventeen Bucladesine ic50 articles were included. Data were extracted by two reviewers and summarized following a systematic scheme. Results Even years

after initial diagnosis, cancer survivors suffer from FoR. Most studies report low or moderate mean FoR scores, suggesting that FoR is experienced in modest intensity by most survivors. Studies including long-term and short-term Go 6983 purchase survivors indicate no significant change of FoR over time. Lower level of education, lower level of optimism, and being Hispanic or White/Caucasian were found to be associated with higher levels of FoR. Significant negative associations were reported between FoR and quality of life as well as psychosocial well-being. All but three studies were conducted in the USA. LOXO-101 General cut-offs for severity/clinical significance have not been defined yet. Conclusions FoR at modest intensity is experienced by most long-term cancer survivors. Future studies

should address determinants and consequences of FoR in more detail. Validated instruments providing cut-offs for severity/clinical significance of FoR should be developed and utilized. Efficient interventions should be implemented to reduce detrimental effects of FoR. Copyright (c) 2012 John Wiley & Sons, Ltd.”
“The interdigital transducer (IDT)/AlN/conducting layer/diamond structures are investigated in this study to design surface acoustic wave (SAW) devices in the super high frequency band. Simulation results using the finite element method show that a thin conducting layer can effectively increase the coupling coefficient and, thus, broaden the bandwidth of SAW devices. For the Sezawa mode, it is illustrated that using a Ti layer with a layer thickness-to-wavelength ratio of 0.02 the maximum coupling coefficient is 2.546% and the associated SAW phase velocity is 10657 m/s at the AlN films’ thickness-to-wavelength ratio of 0.14. This coupling coefficient is 105% higher than that in the IDT/AlN/diamond structure. The research results can be applied to design SAW devices using diamond based structures in the super high frequency band.