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“Purpose: More ambulatory urological surgeries are being performed in children due to innovations in techniques and trends in medical care. Pediatric ambulatory surgery centers are seeing more complex procedures that were traditionally hospital based.

Materials and Methods: A total of 343 open renal and bladder procedures were performed by Birinapant in vitro a single pediatric urologist at a freestanding pediatric surgery center (12 miles from a pediatric hospital) between July 2003 and October 2009. Charts were analyzed to determine the demographics and complications necessitating hospitalization within 48 hours of discharge home.

Results: During the study period 28 children

(mean

age 1.62 years, range 4 months to 6 years) TPX-0005 clinical trial underwent nephrectomy, 50 (2.92 years, 3 months to 12 years) underwent pyeloplasty, 216 (4.01 years, 8 months to 21 years) underwent simple ureteral reimplantation and 49 underwent complex ureteral reimplantation (2.79 years, 5 months to 12 years). Two children were acutely transferred to the hospital, 1 for pain management and 1 for respiratory distress. Two additional children were hospitalized within 48 hours, 1 due to partial ureteral obstruction, and 1 due to dehydration and urinary tract infection. All 4 of these patients underwent simple reimplantation surgery.

Conclusions: Carefully selected children undergoing open renal and bladder procedures can

be expected to be discharged home on the same day. Older children, those with significant comorbidities and those undergoing procedures later in the day may not be ideal outpatient candidates. Nephrectomy, pyeloplasty and ureteral reimplantation are excellent outpatient procedures for most children.”
“In rats, neonatal (+)-methamphetamine (MA) exposure and maternal separation stress increase corticosterone during treatment and result in learning and memory impairments later in life. Early-life stress also changes later responses to acute stress. We tested the hypothesis that neonatal MA exposure would alter adult corticosterone after acute stress or MA challenge. Rats were treated with MA (10 mg/kg x 4/day), saline, or handling on postnatal 2-hydroxyphytanoyl-CoA lyase (P) days 11-15 or 11-20 (days that lead to learning and memory impairments at this dose). As adults, corticosterone was measured before and after 15 min forced swim (FS) or 15 min forced confinement (FC), counterbalanced, and after an acute MA challenge (10 mg/kg) given last. FS increased corticosterone more than FC; order and stress type interacted but did not interact with treatment; treatment interacted with FS but not with FC. In the P11-15 regimen, MA-treated rats showed more rapid increases in corticosterone after FS than controls. In the P11-20 regimen, MA-treated rats showed a trend toward more rapid decrease in corticosterone after FS. No differences were found after MA challenge.