(C) 2010 Wiley-Liss, Inc.”
“Purpose\n\nThe International Prognostic Score (IPS) is the
most widely used risk stratification index for Hodgkin’s lymphoma (HL). It is based on patients treated before 1992 and predicts 5-year freedom from progression (FFP) and overall survival (OS) ranging from 42% to 84% and 56% to 89%, respectively. The IPS has not been validated in a recently Nepicastat research buy treated population in which outcomes have improved compared with historic results.\n\nPatients and Methods\n\nBy using the British Columbia Cancer Agency Lymphoid Cancer Database, we identified all patients age >= 16 years newly diagnosed with advanced-stage HL (stage III to IV, or stage I to II with “B” symptoms or bulky disease >= 10 cm) from 1980 to 2010, treated with curative intent with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) or an ABVD-equivalent regimen with complete clinical information.\n\nResults\n\nIn all, 740 patients were identified. Five-year FFP and OS were 78% and 90%, respectively. The IPS was GDC-0068 purchase prognostic for both FFP (P < .001) and OS (P < .001), with 5-year FFP ranging
from 62% to 88% and 5-year OS ranging from 67% to 98%. Analysis limited to patients age 16 to 65 years (n = 686) demonstrated a narrower range of outcomes, with 5-year FFP ranging from 70% to 88% and 5-year OS ranging from 73% to 98%.\n\nConclusion\n\nThe IPS remains prognostic for advanced-stage HL, but the range of outcomes has narrowed considerably. This improvement in outcome with ABVD should be acknowledged before consideration of alternate initial therapies and when comparing results
from current trials with those of historic controls.”
“Background Robotic colorectal surgery is gaining interest in general and colorectal surgery. The use of the da Vinci (R) Robotic system has been postulated to improve outcomes, primarily see more by increasing the dexterity and facility with which complex dissections can be performed. We report a large, single institution, comparative study of laparoscopic and robotic colectomies, attempting to better elucidate the benefits of robotic surgery in patients with colorectal disease.\n\nMethods We conducted a retrospective review of 171 patients who underwent robotic and laparoscopic colectomies (79 and 92, respectively) at our institution between November 2004 and November 2009. Patients in both groups had well-matched preoperative parameters. All cases were further subdivided by their anatomical location into right-sided and left-sided colectomy, and analysis was performed within these two subgroups.