Clin Rheumatol 23:383–389PubMedCrossRef 31. Miller PD, Shergy WJ, Body J-J, Chen P, Rohe ME, Krege JH (2005) Long-term reduction of back pain risk in women with ATM/ATR inhibitor osteoporosis treated with teriparatide compared with alendronate. J Rheumatol 32:1556–1562PubMed 32. Knopp JA, Diner BM, Blitz M, Lyritis GP, Rowe BH (2005) Calcitonin for treating acute pain of osteoporotic vertebral compression fractures: a systematic review of randomized, controlled trials. Osteoporos Int 16:1281–1290PubMedCrossRef 33. Papadokstakis G, Katonis
P, Damilakis J, Hadjipavlou A (2005) Does raloxifene treatment influence back pain and disability among postmenopausal women with osteoporosis? Eur Spine J 14:977–981CrossRef 34. Papadokostakis G, Damilakis J, Mantzouranis E, Katonis P, Hadjipavlou A (2006) The effectiveness of calcitonin on chronic back pain and daily activities in postmenopausal women with osteoporosis. Eur Spine J 15:356–362PubMedCrossRef BIIB057 datasheet 35. Scharla S, Oertel H, Helsberg K, Kessler F, Langer F, Nickelsen T (2006) Skeletal pain in postmenopausal women with osteoporosis: prevalence and course during raloxifene treatment in a prospective observational study of 6 months duration. Curr Med Res Opin 22:2393–2402PubMedCrossRef”
“Introduction Hip fractures in the aged constitute a major health problem with substantial morbidity [1], mortality [2, 3], and, as the ageing population increases, an increasing
burden on the health care system [4]. Fracture risk varies markedly between KU-57788 countries [5]. In a study by Kanis et al. [6], comparing 10-year probability of hip fracture, all countries except Norway had lower risk than Sweden. Other countries categorized at very high risk (>75% of the risk of Sweden) were Iceland, Denmark and the US. At the age learn more of 80, the estimated probability of sustaining a hip fracture the next 10 years is 8.6% and 17.7% in Norwegian men and women, respectively [7], and a report from the Norwegian capital Oslo calculated an overall annual fracture rate of 118.0 in women and 44.0 in men
per 10,000 [8]. Several recent studies are reporting declining fracture incidence [9–14]. Although the Norwegian hip fracture rates remain the highest reported in the world, data from Oslo in 1996–1997 indicated no increasing incidence rates compared to the 1988–1989 [8].Within Norway, considerable geographic differences have been reported, with substantially lower rates in smaller cities and rural areas compared to Oslo [7, 15]. However, these are reports based on sporadic studies in few regions and in limited time periods [16, 17]. From 1985 to 2003, the Norwegian Institute of Public Health commissioned four Norwegian hospitals, representing 10% of the population, to run a national injury registry [18]. The registry collected a variety of data connected to the actual injury itself and the event leading to the injury.