Drug Alcohol Rev 2007, 296:25–31.CrossRef 35. Satchell JE: Earthworm microbiology. In Earthworm Ecology: From Darwin to Vermiculture. Edited by: Satchell JE. London: Chapman and Hall; 1983:351–365.CrossRef 36. Gao H, Yang Z, Zhang S, Cao S, Shen S, Pang Z, Jiang X: Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution Quisinostat mw and internalization. Sci Rep 2013, 3:2534–2553. doi:10.1038/srep02534

37. Ireland MP, Richards KS: The occurrence and localisation of heavy metals and glycogen in the earthworms Lumbricus rubellus and Dendrobaena rubida from a heavy metal site. Histochenistry 1977, 51:153–166.CrossRef 38. Bystrzejewska-Piotrowska G, Asztemborska M, Giska I, Mikoszewski A: Influence of earthworms on extractability of metals from soils contaminated with Al 2 O 3 , TiO 2 , Zn, and ZnO nanoparticles and microparticles of Al 2 O 3 . Pollut Environ Stud 2012,21(2):313–319. 39. Lunov O, Zablostskii V, Syrovets T: Modeling receptor-mediated endocytosis of polymer-functionalized iron oxide nanoparticles by human macrophages. Biomaterials 2011, 32:547–555.CrossRef 40. Ballarian L, Burighel P: RGD-containing molecules induce macropinocytosis in ascidian hyaline amoebocytes. J Invertebr

Pathol 2006, 91:124–130.CrossRef 41. Franc NC, Dimarcq JL, Lagueux M, Hoffmann J, Ezekowitz RA: Croquemort, a novel Drosophila hemocyte/macrophage check details receptor that recognizes apoptotic cells. Immunity 1996, 4:431–443.CrossRef 42. Lin CY, Zheng QA, Huang SJ, Kuo NJ: Variability of sea surface temperature and warm pool area in the South China Sea and its relationship to the western Pacific warm pool. J Oceanogr 2011,67(6):719–724. doi:10.1007/s 10872–011–0072-xCrossRef 43. Molnar L, Engelmann P, Somogyi I, Mascik LL, Pollak E: Cold-stress induced formation of calcium and phosphorous rich chloragocyte granules (chloragosomes) in the earthworm Eisenia fetida. Comp Biochem Physiol 2012, 163:109–209.CrossRef 44. Beer C, Odbjerg R, Hayashi Y, Sutherland DS, Autrup H:

Toxicity of silver nanoparticle. Toxicol Lett 2012,208(3):286–292.CrossRef 45. Homa J, Zorska A, Wesolowski D, Chadzinska M: Dermal exposure to immunostimulants Megestrol Acetate induces changes in activity and proliferation of coelomocytes of Eisenia andrei. J Comp Physiol 2013, 183:313–322.CrossRef 46. Opper B, Nemeth P, Engelmann P: Calcium is required for coelomocyte activation in earthworms. Mol Immunol 2010, 47:2047–2056.CrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions SG designed the experiment, analysed the data and was involved in drafting the www.selleckchem.com/products/Roscovitine.html manuscript. TK replicated the experiment and statistically analysed the data. SY gave the final approval for publication. All authors read and approved the final manuscript.