Environ Health 18(8):36CrossRef Steiner MF, Dick FD, Scaife AR, Semple S, Paudyal P, Ayres JG (2011) High prevalence of skin symptoms among bakery workers. CB-839 Occup Med (Lond) 61(4):280–282CrossRef van der Lende R, Orie NG (1972) The MRC-ECCS questionnaire on respiratory symptoms (use in epidemiology). Scand J Respir Dis 53(4):218–226 Vanoirbeek JA, Tarkowski M, Ceuppens JL, Verbeken EK, Nemery B, Hoet PH (2004) Respiratory response to toluene diisocyanate depends

on prior frequency and concentration of dermal sensitization in mice. Toxicol Sci 80(2):310–321CrossRef Wisnewski AV (2007) Developments in laboratory diagnostics for isocyanate asthma. Curr Opin Allergy Clin Immunol 7(2):138–145CrossRef Zhang XD, Hubbs AF, Siegel PD (2009) Changes in asthma-like responses after extended removal from exposure to trimellitic AR-13324 datasheet anhydride in the Brown Norway rat model. Clin Exp Allergy 39(11):1746–1753CrossRef”
“Introduction Work-related knee-straining activities such as kneeling or squatting are recognised as risk factors for knee pathologies such as knee osteoarthritis and meniscal tears, a correlation documented by numerous international studies, especially case–control studies (Coggon et

al. 2000; Cooper et al. 1994; Jensen 2005; Klussmann et al. 2010; Selleckchem JIB04 Manninen et al. 2002; Sandmark et al. 2000; Seidler et al. 2008). In these studies, the identification of cases or patients often is based on the elaborate medical examinations including radiography, and the exposure assessment is usually conducted by using self-administered questionnaires (Felson et al. 1991; Muraki et al. 2009; Vingard et al. 1991). This means that study participants have to estimate their daily amount of kneeling or squatting retrospectively, often for work shifts decades ago. Thus, the validity PIK3C2G of the information gained by self-reporting is one major criterion for the quality of these studies. For several kinds of occupational exposures, there are a number of studies showing low validity of self-reporting

and poor correlations with measuring or observation methods, for example manual material handling (Viikari-Juntura et al. 1996), postures of the upper extremities (Descatha et al. 2009; Hansson et al. 2001), and duration of computer use (Douwes et al. 2007; IJmker et al. 2008). In contrast, in the field of work-related knee loading, comparatively few studies related to this topic can be found. Furthermore, their results are not consistent: Some studies showed good agreement between self-reported and observed amount of knee loading (Jensen et al. 2000; Pope et al. 1998), others found poor validity of self-reported quantified knee load (Baty et al. 1986; Bolm-Audorff et al. 2007; Burdorf and Laan 1991; Klußmann et al. 2010; Viikari-Juntura et al. 1996).