Explanatory variables Handwritten selleck product contemporaneous patient records and computerised obstetric and neonatal databases were consulted to complete individual case report forms for each participant. In addition, a detailed OVD proforma completed by the operator immediately following the delivery was assessed for procedural details and immediate delivery outcomes. Maternal and infant characteristics, labour and postnatal details and the outcome measures detailed below were entered in the data set by a research fellow, including morbidities up until the first hospital discharge. Outcome measures The primary outcome measures of interest were maternal and neonatal morbidities following OVDs occurring

during the day (08:00–19:59) and at night (20:00–07:59). Maternal outcomes included postpartum haemorrhage (estimated blood loss >500 mL), third or fourth degree perineal tear (anal sphincter injury), shoulder dystocia and prolonged length of stay (>3 days). Neonatal outcomes included traumatic injury (excluding instrument marks and minor bruising), Apgar scores (subclassified as Apgar score of ≤3 at 1 min or <7 at 5 min), paired cord blood results (subclassified as arterial pH of <7.00) and neonatal intensive care unit

(NICU) admission. Procedural factors included grade of operator, sequential use of instruments, more than three pulls with an instrument (s) and CS after abandoned or failed OVD. Obstetricians at the grade of senior house officer or junior registrar were classified as ‘junior operators’ and typically had between 1 and 3 years’ experience in obstetrics. Obstetricians at the grade of year 1–3 registrar were classified as ‘mid-grade’ operators and had between

3 and 6 years’ obstetric experience. Senior operators included trainees at the grade of registrar year 4 or above, and typically had between 6 and 10 years’ experience. Consultant operators varied, with between 10 and 30 years’ experience, some of whom had fixed daytime sessions on the labour ward. In all cases, where women were transferred to the operating theatre in the second stage of labour, an assessment was made to decide whether to attempt an OVD or to proceed to immediate CS. Statistical analysis The purpose of the cohort study was to gain insights on OVD from an entire Cilengitide population of affected women. A binary variable was created for time of OVD performed during the day (08:00–19:59) and at night (20:00–07:59). We used descriptive statistics for the maternal, neonatal, labour and delivery details to characterise the cohort in relation to the two time periods. Results were reported as ORs and 95% CIs. Multivariable logistic regression analyses were performed to address potential confounding factors. Factors were chosen for the regression analyses primarily based on statistically significant differences between the two groups for baseline clinical and procedural variables.