In such individuals, the decision to recommend MAC prophylaxis will need to balance the potential clinical benefits against the additional pill burden, possible added drug-related toxicity, and risk of resistance if undiagnosed DMAC is present (category IV recommendation). Rifabutin, clarithromycin or azithromycin are acceptable, BEZ235 concentration although azithromycin (1250 mg weekly) is preferred since it has fewer potential drug–drug interactions and is better tolerated (category Ib recommendation). The dose recommended

in this guideline differs from the 1200 mg dose traditionally recommended in other guidelines and reflects the size of azithromycin tablets available in the UK. Primary prophylaxis can be stopped when the patient has a response to HAART (viral load <50 copies per mL) and a CD4 count >50 cells/μL for at least 3 months (category III recommendation). Some physicians prefer to use a cut-off of 100 cells/μL based on evidence from two papers. In these studies, all the patients had CD4 counts Daporinad >100 cells/μL on stopping prophylaxis, but no cases of DMAC and only two cases of atypical focal MAC were seen [47,48]. No data are available for a >50 cells/μL cut-off. However, owing to the effect of antiviral therapy on MAC, the toxicity

of azithromycin seen in prophylaxis studies, and the fact that almost all cases of MAC occur at CD4 counts of less than 50 cells/μL, as evidenced in the Pierce study [46], a cut-off of 50 cells/μL has been considered most appropriate. HAART should be commenced within 2 weeks of starting MAC therapy (category IV recommendation). The incidence of DMAC has dropped dramatically with the use of HAART. HAART should be initiated promptly after diagnosis of MAC and primary and secondary

prophylaxis can be discontinued after an initial response to HAART as outlined above. MAC IRIS can occur as focal disease presenting as regional lymphadenopathy, liver lesions, bone lesions or hypercalcaemia [49–54]. This syndrome is usually self-limiting but can be severe and require adjunctive therapy. There are currently no randomized data to recommend Acesulfame Potassium the optimal management strategy. However, the following have been used with anecdotal benefit (category III recommendation) and may be considered in select cases: 1 Corticosteroid therapy, with 20–40 mg of oral prednisolone a day for 4–8 weeks has been most frequently used; M. kansasii is the second most common nontuberculous mycobacterium producing disease in patients with HIV infection [58]. Pulmonary disease is seen in over half of patients [58–60], and bacteraemia occurs in fewer than 25% of individuals, although disseminated infection is associated with advanced immunosuppression. Presentation is pulmonary in over half of cases [59–61]. The most typical presenting symptoms/features are fever, cough, focal pulmonary signs on examination and radiological features of pulmonary cavities or infiltrates.