In this investigation the gastric floating system employed sodium bicarbonate and citric acid as a gas forming agent dispersed in hydrogel matrix. After reacting with hydrochloride acid, sodium bicarbonate and citric acid creates carbon dioxide BMS-354825 molecular weight whose bubbles were on the surface of the tablets,

caused tablets floating in the fluids more than 12 h in vitro. The extended residence time of drug in stomach could cause increased absorption due to the fact that the upper part of GIT was the main absorption site for cefdinir. Moreover, during formation of the floating tablets, the evolving gas permeated through the matrix leaving gas bubbles or pores, which also increased the release rate of the active ingredient from the matrix. From the results of floating behavior studies

in Table 3 and Fig. 2, it was found that as the concentration of effervescent mixture increased, the floating lag time, floating duration and matrix integrity decreased and vice versa. A reverse trend was observed on increasing the polymer concentration. Therefore the concentration of the effervescent mixture was chosen so as not to compromise the matrix integrity with the possible shortest lag time and floating duration of up to 12 h. The results click here in Table 4 showed that the tablet weight for all batches of polymer blends were at 375 mg, diameter 4.55 mm, thickness between 3.550 mm and 4.327 mm, tablet hardness 7 kg/cm2 and tablet friability

less than 1%. The assay of content of cefdinir varied between 97.92% and 100.45%. Thus all the physical parameters of the manually compressed tablets were quite within specified limits. Initial batch FM 1 & 2, cefdinir floating layer were prepared using HPMC K4M in the absence of sodium bicarbonate and citric acid. The floating layer failed to float and did not remain intact; moreover, 55% of the drug was released within 1 h as shown in Fig. 3 and Fig. 4 at this low concentration of HPMC K4M. Hence the concentration of HPMC K4M was increased for batch FM 2, which showed matrix integrity, but the release of drug was too rapid. In batches FM 3 to FM 7, the concentration mafosfamide of sodium bicarbonate was increased in order to get the desired floating behavior. Furthermore, the polymer concentration was increased in order to achieve the desired release profile from batches FM 8 to FM 12. Formulation FM 10 gave the best results in terms of floating behavior (lag time 1.57 ± 0.52 min, duration 12 h), and drug release was calculated in accordance with dose calculation. The amount dissolved at 1, 2, 4, 6, 8, 10, and 12 h should be 57.57%, 61.97%, 70.78%, 79.55%, 88.58%, 95.36%, and more than 99% as shown in Fig. 3 and Fig. 4, respectively. Batches FM 11and FM 12 showed greater retardation of drug release because of the high concentration of polymer.