Lancet 362:428–432PubMedCrossRef see more 30. Canonico M, Bouaziz E, Carcaillon L, Verstuyft C, Guiochon-Mantel A, Becquemont L, Scarabin PY, Estrogen and Thromboembolism Risk (ESTHER) Study Group (2008) Synergism between oral estrogen therapy and cytochrome P450 3A5*1 allele on the risk of venous thromboembolism among postmenopausal women. J Clin Endocrinol Metab 93:3082–3087PubMedCrossRef 31. Cummings SR, Ettinger B, Delmas PD, Kenemans P, Stathopoulos V, Verweij P, Mol-Arts M, Kloosterboer L, Mosca L, Christiansen C, Bilezikian J, Kerzberg EM, Johnson S, Zanchetta J, Grobbee DE, Seifert W, Eastell R (2008) The effects of tibolone in older postmenopausal women. N Engl J Med 359:697–708PubMedCrossRef

32. Gompel A, Rozenberg S, Barlow DH (2008) The EMAS 2008 update on clinical recommendations on postmenopausal

hormone replacement therapy. Maturitas 61:227–232PubMed 33. Lekander I, Borgström F, Ström O, Zethraeus N, Kanis JA (2009) Cost-effectiveness of hormone therapy in the United States. J Womens Health (Larchmt) 10:1669–1677CrossRef 34. Bagger YZ, Tanko LB, Alexandersen P, Hansen HB, Mollgaard A, Ravn P, Qvist P, Kanis JA, Christiansen C (2004) Two to three years of hormone replacement treatment in healthy women have long-term preventive effects on bone mass and osteoporotic fractures: the PD0332991 cell line PERF study. Bone 34:728–735PubMedCrossRef 35. Alexandersen P, Toussaint A, Christiansen C, Devogelaer JP, Roux C, Fechtenbaum J, Gennari C, Reginster JY (2001) Ipriflavone in the treatment of postmenopausal osteoporosis: Oxymatrine a randomized controlled trial. JAMA 285:1482–1488PubMedCrossRef 36. Alekel DL, Germain AS, Peterson CT, Hanson KB, Stewart

JW, Toda T (2000) Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 72:844–852PubMed 37. Hsu CS, Shen WW, Hsueh YM, Yeh SL (2001) Soy isoflavone supplementation in postmenopausal women. Effects on plasma lipids, antioxidant enzyme activities and bone density. J Reprod Med 46:221–MK-4827 clinical trial 226PubMed 38. Chen YM, Ho SC, Lam SS, Ho SS, Woo JL (2003) Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial. J Clin Endocrinol Metab 88:4740–4747PubMedCrossRef 39. Kreijkamp-Kaspers S, Kok L, Grobbee DE, de Haan EH, Aleman A, Lampe JW, van der Schouw YT (2004) Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA 292:65–74PubMedCrossRef 40. Nikander E, Metsa-Heikkila M, Ylikorkala O, Tiitinen A (2004) Effects of phytoestrogens on bone turnover in postmenopausal women with a history of breast cancer. J Clin Endocrinol Metab 89:1207–1212PubMedCrossRef 41. Seeman E, Crans GG, Diez-Perez A, Pinette KV, Delmas PD (2006) Anti-vertebral fracture efficacy of raloxifene: a meta-analysis. Osteoporos Int 17:313–316PubMedCrossRef 42.