PubMedCrossRef 23 Bianchi F, Nicassio F, Di Fiore PP: Unbiased v

PubMedCrossRef 23. Bianchi F, Nicassio F, Di Fiore PP: Unbiased vs. biased approaches to the identification of cancer signatures: the case of lung cancer. Cell

Cycle 2008, 7:729–734.PubMedCrossRef 24. Guan P, Huang D, He M, Zhou B: Lung cancer gene expression database analysis incorporating prior knowledge with support Selleck SBE-��-CD vector machine-based classification method. J Exp Clin Cancer Res 2009, 28:103.PubMedCrossRef 25. Nakashima RA, Paggi MG, Pedersen PL: Contributions of glycolysis and oxydative phosphorylation to adenosine-5′-triphosphate production in AS-30D hepatoma cells. Cancer Res 1984, 44:5702–5706.PubMed 26. Nakashima RA, Paggi MG, Arora KK, Pedersen PL: Integration of mitochondrial function with high aerobic glycolysis in tumors: role of https://www.selleckchem.com/products/ly-411575.html Hexokinase binding to the outer mitochondrial membrane. In Integration of Mitochondrial Function. learn more Edited by: Lemasters JJ, Hackenbrock CR, Thurman RG, Westhoff HV. New York, N.Y.: Plenum Publishing Company; 1990:405–411. 27. Wallace DC: Mitochondria and cancer: Warburg addressed. Cold Spring Harb Symp Quant Biol 2005, 70:363–374.PubMedCrossRef 28. Pedersen PL: Warburg, me and Hexokinase 2: Multiple discoveries of

key molecular events underlying one of cancers’ most common phenotypes, the “”Warburg Effect”", i.e., elevated glycolysis in the presence of oxygen. J Bioenerg Biomembr 2007, 39:211–222.PubMedCrossRef 29. Brickley DR, Mikosz CA, Hagan CR, Conzen SD: Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1). J Biol Chem 2002, 277:43064–43070.PubMedCrossRef 30. Mattmann ME, Stoops SL, Lindsley CW: Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape. Expert Opin Ther Pat 2011, 21:1309–1338.PubMedCrossRef 31. Morrow JK, Du-Cuny L, Chen L, Meuillet EJ, Mash EA, Powis G, et al.: Recent development of anticancer therapeutics targeting Akt. Recent Pat

Anticancer Drug Discov 2011, 6:146–159.PubMedCrossRef 32. Hixon ML, Paccagnella L, Millham R, Perez-Olle R, Gualberto A: Development of inhibitors of the IGF-IR/PI3K/Akt/mTOR pathway. Rev Recent Clin Trials 2010, 5:189–208.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions CA: Research planning, Dipeptidyl peptidase IHC and qPCR determinations, statistical analysis. SM: Research planning, IHC and qPCR determinations, statistical analysis. LP: Research planning, collection of patients’ information, manuscript drafting. AMM: Research planning and qPCR determinations. PV: Patients’ diagnosis, IHC scoring. BA: Tissue slices preparation, haematoxylin/eosin staining. GA: Collection of patients’ information, patients’ database maintenance. FF: Surgery and patients’ database maintenance. RA: qPCR determinations. LD’A: qPCR determinations. MR: Research planning, collection of patients’ information, manuscript drafting. AF: Research planning, qPCR determinations, statistical analysis.

Comments are closed.