Results: There was no significant difference between the reoperation rates for the two groups. In total, five patients (three from the long-gamma-nail group and two from the sliding-hip-screw group) underwent revision surgery because of cut-out. Tip-apex distance was found to correlate with the implant cut-out rate. There was no significant difference between the two groups in terms of the EuroQol 5D outcome scores, the mortality rates after correction for the mini-mental score, or any of the secondary outcome measures.
Conclusions:
When compared with the long gamma nail, the sliding hip screw should remain the gold standard for the treatment of AO/OTA 31-A2 3-MA fractures of the proximal part of the femur because it is associated with similar outcomes with less expense.”
“Introduction: About 30-40% of patients with acute severe ulcerative colitis (UC) fail to respond to intensive find more intravenous (iv) corticosteroid treatment. lv cyclosporine and infliximab are an effective rescue therapy in steroid-refractory UC patients but up to now it is still unclear which is the best therapeutic choice.
Methods: We reviewed our series of severe steroid-refractory colitis admitted consecutively since 1994 comparing two historical
cohort treated with iv cyclosporine (2 mg/kg) or iv infliximab (5 mg/kg). The main outcome was the colectomy rate at 3 months, 12 months and at the end of the follow-up.
Results: A total of 65 patients were included: 35 in the cyclosporine group and 30 in the infliximab one. At 3 months the colectomy rate was Luminespib 28.5% in the cyclosporine group and 17% in the infliximab
group (p = 0.25), while 48% versus 17% at 12 months (p = 0.007, OR 4.7; 95% CI: 1.47-15.16). The 1-2-3 year cumulative colectomy rates were 48%, 54%, 57% in the cyclosporine group, and 17%, 23%, 27% in the infliximab group. At the end of the follow-up the colectomy rate was 60% versus 30% (p = 0.04, HR 2.2; 95% CI: 1.11-4.86). High level of C reactive protein (p = 0.04), extensive disease (p = 0.01) and no azathioprine treatment (p<0.001) were related to the risk of colectomy.
Conclusion: This study, despite being retrospective, indicates that both cyclosporine and infliximab are effective in avoiding a colectomy in steroid-refractory UC patients. During the follow-up the risk of a colectomy is higher in patients treated with cyclosporine than with infliximab. (C) 2012 European Crohn’s and Colitis Organisation. Published by Elsevier B.V. All rights reserved.”
“Background: Research on the relationship between orthopaedic volume and outcomes has focused almost exclusively on elective arthroplasty procedures.