The magnitude of plasma 3-OMG increase was directly related to the rise in post-prandial blood glucose (r = 0.78, P < 0.01), which were significantly higher in the obese than healthy volunteers (P < 0.0001). During fasting, mRNA expression of SGLT-1 but not GLUT2 was higher in obese than healthy subjects (P = 0.05). In the obese, but not the healthy, mRNA

expression of SGLT-1 was reduced after glucose stimulation (P = 0.01). In contrast, the opposite pattern was observed with GLUT2 expression, with a trend for mRNA expression of GLUT2 to be reduced after Z-IETD-FMK research buy glucose exposure in the healthy (P = 0.06), but not the obese. The mRNA expression of SGLT-1 during fasting was related to the peak plasma 3-OMG learn more concentrations (r = 0.60, P = 0.02), whilst expression of GLUT2 30 mins after glucose exposure was positively correlated with integrated 3-OMG concentrations (r = 0.52, P = 0.04) Conclusion: The rate of glucose absorption in the proximal intestine is accelerated in morbid obesity and impacts on glycaemic excursions. This dysregulation of glucose absorption is associated with an increased expression of SGLT-1 during fasting, and is correlated positively with the expression

of GLUT-2 after glucose stimulation. These findings provide novel evidence of a complex dysregulation of intestinal glucose transportation and absorption in morbid obesity, which may mediate the weight gain and type 2 diabetes of obesity. Key Word(s): 1. obesity; 2. glucose transporter; 3. glucose absorption; 4. dysregulation; Presenting Author: FATEMEH HAIDARI Additional Authors: MAJID MOHAMMADSHAHI, MEHRNOUSH ZAKERZADEH, SAMIRA HASHEMI Corresponding Author: FATEMEH HAIDARI, MAJID MOHAMMADSHAHI Affiliations: Ahvaz Jundishapur University of Medical Sciences Objective: There is little information regarding the relationship between maternal dietary pattern and infant anthropometric parameters at birth. So the present study was carried out to determine the association of dietary patterns in pregnancy and infant anthropometric parameters. 上海皓元医药股份有限公司 Methods: In this cross-sectional study, 94 pregnant women (37–40 weeks) referred to Ahvaz Razi hospital were selected. Anthropometric

data were collected by individual questionnaire and dietary intakes were assessed by a semi-quantitative food frequency questionnaire. Factor analysis was used to identify dietary patterns. Statistical analysis was performed by SPSS software. Results: In this study, 3 major dietary patterns were identified: “healthy”, “traditional” and “western” dietary patterns. After adjusting for confounders (age, physical activity, energy intake, pregnancy weight gain and infant sex), the association of dietary patterns with birth weight, height and head circumference was exhibited in 3 models. The relationship between healthy dietary pattern and infant weight, height and head circumference at birth was significantly positive in 3 models (p < 0.05).