The median follow up time was 1. 63 years for RA patients add to favorites and 1. 64 years for non RA patients, accounting for 91,315 person years in RA subjects and 488,929 person years in non RA patients. Patient characteristics Baseline characteristics of the age and sex matched cohorts were compared. The median age was 55 years and 73% were women in both cohorts. Sub stantial differences across almost all other baseline char acteristics were observed between the cohorts, with the prevalence of fracture risk factors much more common in RA patients than non RA subjects. A recorded diag nosis of osteoporosis, comorbidity, oral glucocorticoid use, and health care utilization including physician visits and hospitalization were more commonly noted in patients with RA.

Incidence rates of any fracture During the study follow up, 3,968 patients of the study population experienced a fracture. As shown in Table 2, the IR of fracture at any of the four sites among RA Inhibitors,Modulators,Libraries patients was 9. 6 per 1,000 person years and 1. 5 times higher than that of non RA patients. The RRs of experiencing Inhibitors,Modulators,Libraries any osteoporotic fractures among RA patients compared with non RA ranged from 1. 35 to 2. 13. Similar age trends were observed in the stratified analyses by sex. Incidence rates of fracture by anatomic sites Site specific fracture IRs were calculated for hip, wrist, humerus, and pelvis. Among the RA patients, humerus fracture had the lowest IR and hip fracture the highest. The IR for humerus fracture was also lowest among non RA patients, but the IR for wrist fracture was the highest.

Among women with RA, the highest IR was noted for pelvis fracture. The fracture IR at hip was 3. 8 per 1,000 person years. In Inhibitors,Modulators,Libraries male RA patients, the fracture IR was 2. 4 per 1,000 person years at hip and 1. 5 per 1,000 person years at pelvis. The RRs were elevated across all anatomic sites for both men and women, ranging from 1. 12 to 2. 05, except those for wrist fracture for both men and women, and humerus fracture for men. Adjusted risks of fracture among patients with RA All the variables listed in Table 1 were adjusted by fit ting multivariable Cox proportional hazards models. The adjusted hazard ratio for any fracture was 1. 26 in RA patients compared with non RA.

Age, female sex, osteoporosis drugs, SSRIs, anticonvulsants, and opioids, history of Parkin sons disease, prior fall and fracture, and hospitalization, numbers of physician visits and prescription drugs, Inhibitors,Modulators,Libraries and the comorbidity index were independently Inhibitors,Modulators,Libraries associated with an increased risk www.selleckchem.com/products/ganetespib-sta-9090.html of fracture. Prior use of oral glucocorticoids also increased a risk of osteoporotic fracture. Furthermore, the adjusted HRs were consistently ele vated in RA patients across all age and sex groups. Additional multivariable Cox regression ana lyses showed increased HRs associated with RA for fractures at the hip and pelvis, but not for humerus or wrist fractures.