The median

lifespan estimated from the 371 individuals in the international fibrodysplasia ossficans progressiva community who were alive and the sixty who had died was fifty-six years (95% confidence interval, fifty-one to sixty years). The most common causes of death in patients with fibrodysplasia ossificans progressiva were cardiorespiratory failure from thoracic insufficiency syndrome (54%; median age, forty-two years) and pneumonia (15%; median age, forty years).

Conclusions: Fibrodysplasia ossificans progressiva is not only an extremely disabling disease but also a condition of considerably shortened lifespan. The most common cause of death in patients with fibrodysplasia ossificans progressiva is cardiorespiratory failure from thoracic insufficiency syndrome.”
“BackgroundPneumonia frequently affects solid organ transplant (SOT) recipients, with high morbidity and mortality. BB-94 datasheet However, the few studies on pneumonia in this population are mainly retrospective, single-center, and long-term studies, or include patients with only one type of SOT or a specific etiology. We performed a point prevalence study to investigate epidemiology, diagnosis, therapy, and outcome of pneumonia in an unselected SOT population.

MethodsItalian and Spanish transplant centers were invited to report on GW4064 in vivo all SOT recipients with pneumonia treated during 2 separate weeks (1 each in February and June 2012).

ResultsIn total,

35 centers (18 in Italy, 17 in Spain) agreed to participate and collected 54 cases. The incidence of pneumonia was 10.1 episodes/1000 recipients/year. Pneumonia was classified as late (>6months) in 70.4% of cases. Pneumonia was also classified as community-acquired (CAP), healthcare-associated (HCAP), and hospital-acquired (HAP) pneumonia in 40.7%, 38.9%, and 20.4% of cases, respectively. An attempt to microbiological diagnosis (1 sample) was made in 94.4% of patients, with a diagnostic yield of 60.7%.

Causative agents included bacteria (87.1%), virus (29%), and fungi (6.4%). A multidrug-resistant bacterium was isolated in 18.2%, 40%, and 100% of patients with CAP, HCAP, and HAP (P=0.007), respectively. Overall, 11.1% LY2835219 nmr of patients were admitted to the intensive care unit, 3.7% developed graft rejection, and graft function deteriorated in 18.5%. In-hospital mortality was 1.9%.

ConclusionPneumonia remains a frequent problem in SOT recipients, although it occurs later in patients who are in better physical health. Therefore, harmful pathogens and worse outcome are less common than previously thought.”
“Background: Accurate analysis of osseous glenoid morphology is important in treating glenohumeral arthritis and instability. Two-dimensional computed tomography scans are used to evaluate glenoid alignment. Accuracy of this method is dependent on the angle of axial reconstruction in relation to the position of the scapula.