The precipitate, when well washed and dried, is pure phosphat of www.selleckchem.com/products/Vorinostat-saha.html lime.�� (section PHOSPHAT). One can see that the basics of this process are still used to produce chemically pure calcium orthophosphates from the natural resources (phosphate ore and bones). In 1819, the major properties were described as follows22: ��4. Phosphate of lime is a white insoluble powder, destitute of taste, and unaltered by exposure to air. It is soluble in hydrochloric (muriatic) and nitric acids, and may be precipitated from solution in them by means of ammonia. When exposed to a very violent heat, it undergoes a kind of fusion, and is converted into a white semi-transparent porcelain.�� (ref. 22, p. 327).

However, that knowledge on the thermal properties of phosphate of lime was based on the Fourcroy��s investigations19: ��The pho?phate of lime is extremely difficult to fuse; neverthele?s, by ?trong fire, ?uch as that of a gla?s-house, it ?oftens and acquires a ?emi-tran?parence like the grain of porcelain.�� (ref. 19, p. 341). Thus, calcium phosphate ceramics has been known, since, at least, 1804. In the 4th edition of Encyclop?dia Britannica (1810), applications of calcium orthophosphates were described as follows24: ��The pho?phate of lime is of great importance in chemi?try, for the purpo?e of extracting pho?phoric acid, to be decompo?ed to obtain pho?phorus. It is also employed for making cupels, for poli?hing metals and precious ?tones, and for removing ?pots of grea?�� from linen, paper, and ?ilk. It is u?ed in medicine as a remedy for rickets, to correct the ?uppo?ed effects of acids in ?oftening the bones.

�� (ref. 24, p. 585). Although it is slightly beyond the subject, one should mention, that calcium phosphite (Ca3(PO3)2) is also mentioned in that edition of Encyclop?dia Britannica, as ��pho?phite of lime�� (ref. 24, p. 586). A chemical term ��tribasic phosphate of lime,�� which fully corresponds to ��-TCP and ��-TCP, has been known since, at least, 1832 (ref. 25, p. 90). Concerning publications in scientific journals, in the first half of the 19th century, research papers on calcium apatites and other calcium orthophosphates were published by the famous Swedish chemist J?ns Jacob Berzelius (1779 �C 1848),26,27 as well as by M. Baruel28 and J.D. Smith.29 For example, in a book by Bache, published in 1819,22 the following statement on the Berzelius��s contribution was published: ��5.

According to an analysis by Berzelius, calculated in numbers, in which the equivalent number for lime is assumed, phosphate of lime is composed of Phosphoric acid 34?3�� Lime 29?0��one atom; so that it appears that the composition of this salt cannot be reconciled with the atomic theory.�� (ref. 22, p. 327). However, as early as 1804, Fourcroy19 wrote: ��100 parts of pho?phate AV-951 of lime contain, according to the analy?is of Citizens Fourcroy and Vauquelin, Pho?phoric acid 41 Lime 59�� (ref. 19, p.