These results may contribute for the development of a novel thera

These results may contribute for the development of a novel therapeutic methodology

to treat Lewis y positive cancers. Acknowledgements This work was supported by grants from The National selleck kinase inhibitor Natural AZD1080 Science Foundation of China (30170980, 30571958, 30872757); item of Educational Department Science foundation of Liaoning Province (20121268) and item of Liaoning Natural Science foundation (20052107); item of Educational Department Doctor Startup Fund (20070159023); item of Educational Department Key Laboratory of Liaoning Province (2008S247); Shengjing Freedom researchers plan (200807). References 1. Kitamura K, Stockert E, Garin-Chesa P, Welt S, Llovd KO, Armour KL, Wallace TP, Harris WJ, Carr FJ, Old LJ: Specificity analysis of blood group Lewis-y Le(y) antibodies generatedagainst synthetic

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node negative breast carcinomas. Breast Cancer Res 2005, 7: R780-R787.CrossRefPubMed 6. Kim YS, Yuan M, Itzkowitz SH, Sun QB, Kaizu T, Palekar A, Trump BF, Hakomori S: Expression of LeY and extended LeY blood group-related antigens in human malignant, premalignant, and nonmalignant colonic tissues. Cancer Res 1986, 46: 5985–5992.PubMed 7. Yin BW, Finstad CL, Kitamura K, Federici MG, Welshinger M, Kudrvashov V, Hoskins WJ, Welt S, Lloyd KO: Serological and immunochemical analysis of Lewis y (Ley) blood group antigen expression in epithelial ovarian cancer. 3-oxoacyl-(acyl-carrier-protein) reductase Int J Cancer 1996, 65: 406–412.CrossRefPubMed 8. Iwamori M, Tanaka K, Kubushiro K, Lin B, Kiguchi K, Ishiwata I, Tsukazaki K, Nozawa S: Alterations in the glyolipid composition and cellular properties of ovarian carcinoma-derived RMG-1 cells on transfection of the α1,2-fucosyltransferase gene. Cancer Sci 2005, 96: 26–30.CrossRefPubMed 9. Zhao Y, Lin B, Hao YY, Yan LM, Liu JJ, Zhu LC, Zhang SL: The effects of Lewis(y) antigen content on drug resistance to carboplatin in ovarian cancer line RMG-I. Prog Biochem Biophys 2008, 35: 1175–1182. 10.

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