This paper outlines their achievements and challenges, and reflects on current regional needs and what the future may hold for research ethics and bioethics training in Latin America and the Caribbean.”
“Aim: The aim of this study was to evaluate the quality of a new set of clinical Torin 2 practice guidelines

developed by the Czech Neurological Society between 2009 and 2012 using the methodology developed by the National Reference Centre. Methods: Six neurological clinical practice guidelines were evaluated by four independent reviewers with AGREE II instrument in six domains: scope and purpose, stakeholder involvement, rigor of development, clarity and presentation, applicability, and editorial independence. Results: All evaluated clinical practice guidelines were of high quality with the mean of 93.5% for the total score domain. The guidelines had high

scores in the clarity and recommendations and applicability (99.6%), scope and purpose (99.0%), rigour of development (97.6%) and stakeholder involvement (97.1%). The lowest score was in editorial independence (47.5%). RG-7388 Apoptosis inhibitor Conclusions: The overall quality of neurology clinical practice guidelines was high. The methodology of development and support for developers was robust, systematic and standardised. To maintain the quality of development of clinical practice guidelines in the future it is crucial to continue using a comprehensive Selisistat inhibitor and validated development framework. The quality of guidelines can be improved by increasing stakeholder involvement, continuous and systematic assessment of their quality and content and their impact on inputs, processes and outcomes of health care as well as ensuring their effective implementation.”
“Sun YH, Reid B, Fontaine JH, Miller LA, Hyde DM, Mogilner A, Zhao M. Airway epithelial wounds in rhesus monkey generate ionic currents that guide cell migration to promote healing. J Appl Physiol 111: 1031-1041, 2011. First published June 30, 2011; doi:10.1152/japplphysiol.00915.2010.-Damage

to the respiratory epithelium is one of the most critical steps to many life-threatening diseases, such as acute respiratory distress syndrome and chronic obstructive pulmonary disease. The mechanisms underlying repair of the damaged epithelium have not yet been fully elucidated. Here we provide experimental evidence suggesting a novel mechanism for wound repair: endogenous electric currents. It is known that the airway epithelium maintains a voltage difference referred to as the transepithelial potential. Using a noninvasive vibrating probe, we demonstrate that wounds in the epithelium of trachea from rhesus monkeys generate significant outward electric currents. A small slit wound produced an outward current (1.59 mu A/cm(2)), which could be enhanced (nearly doubled) by the ion transport stimulator aminophylline.