To prevent presumptive mortality and morbidity, ROHHAD syndrome should be considered in all cases of rapid and early-onset obesity associated with hypothalamic-pituitary endocrine dysfunctions.”
“Studies in laboratory rodents are shedding light on the find more pathophysiology of testicular
ageing and now suggest a complicated basis for age-related declines in testicular function. A highly significant contributor to infertility may involve failure of specific and complex testicular microenvironments (niches) comprised of a variety of cellular and molecular components. Our laboratory has applied testis tissue xenografting to the study of testicular ageing in the stallion. Using this technique, we have confirmed that the disease is selleck kinase inhibitor tissue autologous. As would be expected from a tissue autologous disease, hormonal and non-hormonal therapies designed to drive the function of the diseased testis are ineffective. However, we have some evidence that contact
with young, normal testicular tissue may improve the condition of aged, degenerate testes. Perhaps, paracrine factors from young testicular cells may partially restore a young microenvironment and allow for the maintenance of testicular function. These findings form the basis for future studies designed to determine whether cells, genes or proteins from a normal testis can aid the function of a degenerate testis.”
“Objective. To explore
whether epidural analgesia (EA) in labor is independent risk factor for neonatal pyrexia after controlling for intrapartum pyrexia.
Methods. Retrospective observational study of 480 consecutive term singleton infants born to mothers who received EA in labor (EA group) and 480 term infants delivered to mothers who did not receive EA (NEA group).
Results. Mothers in the EA group had significantly higher incidence of intrapartum pyrexia [54/480 (11%) vs. 4/480 (0.8%), OR = 15.1, p < 0.0001] and neonatal pyrexia [68/480 (14.2%) vs. 15/480 (3.1%), OR = 5.1, p < 0.0001]. Neonates in the EA group had a median duration of pyrexia of 1 h (maximum 5 h) with a peak temperature within 1 h. Stepwise logistic regression analysis showed that INCB024360 nmr maternal EA was independent risk factor for neonatal pyrcxia (> 37.5 degrees C) after controlling for intrapartum pyrexia (> 37.9 degrees C) and other confounders (OR = 3.44, CI = 1.9-6.3, p < 0.0001). Sepsis work-up was performed significantly more frequently in infants in the EA group [11.7% vs. 2.5%, OR = 5.2, CI = 2.7-9.7, p < 0.0001] with negative blood cultures.
Conclusions. EA in labor is an independent risk factor for pyrexia in term neonates. It is unnecessary to investigate febrile offspring of mothers who have had epidurals unless pyrexia persists for longer than 5 h or other signs or risk factors for neonatal sepsis are present.