Use of a best-evidence synthesis is a next best solution and is a transparent method commonly applied in the field of musculoskeletal disorders when statistical pooling is not feasible or clinically viable (van Tulder et al., 2003). Secondly, for the included recent and additional RCTs we assessed the methodological quality using the list of Furlan et al. (2009). This list includes minimum criteria for which either empirical evidence existed that confirmed they were associated with bias. This list is constructed Belinostat cell line to assess interventions in the field of neck and back disorders, but can also be used and appears

very suitable in other fields (Verhagen et al., 1998 and Boutron et al., 2005). Thirdly, we adopted the quality score and definition of high/low quality for the RCTs included in the three Cochrane reviews. This choice is arbitrary. However, because these included RCTs did not reported significant results, our final conclusions remain

unchanged if would have used the quality list of Furlan et al. (2009). In conclusion, we found moderate evidence in favour of surgery compared to physiotherapy in the mid- and long-term to treat small or medium sizes RotCuffTears. In surgery, GW-572016 chemical structure tendon-to-bone fixation with 1 metal suture anchor loaded with TB was more effective than a side-to-side repair with SS, but further no unequivocal evidence was found that one surgical treatment is superior to the PLEK2 other in treating the RotCuffTear. Further, it remains unclear whether immobilization, or perhaps some form of exercise therapy, is most effective after surgery. Therefore, at present, it is hard to draw firm evidence-based conclusions about the effectiveness of either non-surgical or surgical interventions for RotCuffTears. The whole area of treatment options for RotCuffTears remains mostly

unclear and more research is definitely needed. Future large-scale studies should also concentrate on prognostic factors and on subgroup analyses with regard to the different types of RotCuffTears. There are no conflicts of interest for any authors. The authors thank M.S. Randsdorp, MD, for her participation in the methodological quality assessment. “
“First, The Japanese Society of Child Neurology expresses its heartfelt condolences to all affected by the Great East Japan Earthquake. It is our sincere hope that the affected regions recover as quickly as possible. The Japanese Society of Child Neurology conducts its activities for the benefits of children, the focus of our society. In this spirit, we hereby make a special request to members of the mass media. The Great East Japan Earthquake affected a large part of eastern Japan, and children, even those outside of the affected regions, experienced tremors and blackouts. We therefore believe that such children could well experience emotional trauma if exposed to news footage of destruction from the disaster.