Vascular involvement in MIDs has a strong impact on the prognosis and outcome of these patients. (C) check details 2012 Elsevier B.V. All rights reserved.”
“The temperature dependence of the dielectric properties and ac

conduction of YMnO3 ceramics annealed under different atmospheres is investigated from 25 to 700 degrees C. The origin of the dielectric anomalies is clarified. Two dielectric peaks in the permittivity accompanied by a single anomaly in the dielectric losses characterize the dielectric response. Simultaneously, three different regions can be distinguished in the temperature dependence of ac conductivity. Oxygen vacancies with an activation energy for the conduction of 1.13 eV are suggested to be responsible for the dielectric anomaly observed at < 400 degrees C. For temperatures > 400 degrees C, the dielectric data are influenced by conductivity and no ferroelectric anomaly is obvious. (C) 2011 American Institute of Physics. [doi:10.1063/1.3629996]“
“Recent studies indicate that the majority of the genome is transcribed, however only a fraction of this transcription is annotated as what we traditionally know as genes.

Much of this is low level pervasive, and often overlapping transcription, for which the transcript structure and function, has not as yet been determined. Novel RNAs (and novel classes of RNAs), are now being identified by groups using next generation sequencing and cDNA libraries that target specific sub-fractions of the transcriptome Entinostat mechanism of action (based upon size, modifications, localization and protein interactions). We discuss the state of the art as to measuring and identifying these

novel RNAs and speculate on whether a universal approach to transcript isoform Torin 2 and expression level measurement is possible in the near future.”
“Background and aims: To examine trends in initiation and continuation of statin treatment after myocardial infarction (MI) and their determinants, during a period of increasing usage.

Methods and results: 9367 patients aged 30-84 with a first Myocardial Infarction (MI) in 1997-2006 were identified in DIN-LINK, an anonymised, UK primary care database. We assessed statin initiation (prescription within 6 months of MI) and continued therapy (% covered by a prescription on a given day of those prescribed a statin within 6 months). The influences of co-morbidities and socio-economic deprivation (Index of Multiple Deprivation) were examined.

Statin initiation increased from 37% for MIs in 1997 to 92% in 2006. Continuation at 1 year remained stable over successive cohorts at approximately 80%, settling to about 76% in patients with 5-10 years follow up.