We could confirm that chemotherapy does not indicate surgery contraindication nor increases postoperative morbi-mortality by a significant amount.

This fact, showing the safety of preoperative chemotherapy, could be another reason to believe that neoadjuvant therapy could have a role to play in patients with locally advanced colon cancer. Conclusions Neoadjuvant chemotherapy as a systemic treatment for stage IV colon Inhibitors,research,lifescience,medical cancer does not associate with a high postoperative complication risk. Acknowledgements Disclosure: The authors declare no conflict of interest.
Colorectal cancer is one of the most common cancer worldwide .Its Ipatasertib price incidence is reported to be increasing in developing countries, probably due to the acquisition of a western lifestyle. The highest rate of incidence of colorectal malignancy

occurs more commonly in developed countries like North America, Western Europe with usual mode of presentations like weight loss, anaemia, lump abdomen Inhibitors,research,lifescience,medical for right side and tenesmus, change of bowel habit, obstruction, fresh rectal bleeding for left side. Beside these common modes of presentations, there are some manifestations which masqueraded as different disease like obstructive jaundice, empyema gall bladder or cholecystitis. Here we present a case of carcinoma of proximal part of transverse colon that caused diagnostic confusion by mimicking as gall Inhibitors,research,lifescience,medical bladder cancer. Case report A 60-year-old male presented to hospital with Inhibitors,research,lifescience,medical one year history of right sided pain abdomen, associated with upper GI symptoms like nausea, vomiting. There was no history of weight loss, GI obstruction or blood in stool. Clinical examination revealed pallor. On abdominal examination mild tenderness was present in right hypochondrium. A palpable mass of about 3-4 cm present in right upper Inhibitors,research,lifescience,medical quadrant with rounded lower margins, moving with respiration and continuous with liver dullness. Routine

investigations showed Hb 7 g/mL. TLC, DLC, RFT, PTI and LFT were within normal limit. Bone marrow examination done for persistant anemia despite many of blood transfusion showed iron deficiency anaemia. Ultrasound abdomen showed thickened gall bladder wall with polyp suggestive of malignancy however magnetic resonance cholangiopancreatography (MRCP) revealed cholecystitis with one small polyp as the only findings (Figure 1). Laparoscopic cholecystectomy was attempted. Intra operatively, gall bladder was adherent to liver bed, adjoining gut and omentum. There was difficulty separating gall bladder from adjoining structures for which the procedure was converted to open cholecystectomy. Gall bladder was separated from the adjoining gut, peritoneum and liver bed. On further exploration, there was a large mass in the vicinity of the gall bladder related to transverse colon. Extended right hemicolectomy along with cholecystectomy was performed.