Methods: Chronic hepatitis B (CHB) patients who were admitted to the Second Hospital of Hebei Medical University for a liver biopsy from January 2005 to December 2012 were enrolled. CHB patients were divided into HBeAg-positive and HBeAg-negative groups according to hepatitis B virus (HBV) serum markers HbsAg and HbeAg. At the same time, gender, age, alanine aminotransferase (ALT) and HBV

DNA viral load were recorded, and statistically analyzed with SPSS l3.0. Measurement data were presented as mean ± standard deviation (mean ± SD). Comparing two sample number, t test (for normal distribution) or Mann-Whitney test (for skewed distribution) ABT-888 price was used. ANOVA test was used to compare groups of measurement data. Correlation R788 order analysis was done using Pearson test. For enumeration data, Chi-square was

conducted. Results: One hundred and fifty-eight CHB patients were divided into HBeAg-positive group (86 cases) and HBeAg-negative group (72 cases) based on serum markers HbeAg. Two groups of the age difference was statistically significant (t = −7.50, P < 0.01), no statistically significant differences in the sex ratio (χ2 = 0.10, P > 0.05). There was significant difference in the constitute ratio of liver fibrosis staging between HBeAg positive group and HBeAg-negative group (χ2 = 20.79, P < 0.01). The fibrosis staging integral in HBeAg-positive women were lower than men (1.48 ± 0.69 vs 2.09 ± 1.29, P < 0.05). For HBeAg-positive patients,

both inflammation grading and fibrosis stage points in over 40 year old group were higher than the 30–40 age group and less-than-30-year-old age group with 上海皓元医药股份有限公司 statistical significance (P < 0.05). For HBeAg-negative patients, fibrosis stage points in less-than-30-year-old age group were lower than the 30–40 age group and over 40 year old group with statistical significance (P < 0.05). In HbeAg positive/negative group, age and inflammation grading or fibrosis staging integral were a positive correlation (P < 0.05). In HbeAg positive group, ALT levels and inflammation grading or fibrosis stage integral were positively correlated (P < 0.05). In HbeAg negative group, ALT levels and inflammation grading integral were positively correlated (P < 0.01), ALT levels and fibrosis stage integral were non-related (P > 0.05). There was significant difference in the constitute ratio of the viral load between HBeAg positive group and HBeAg-negative group (χ2 = 38.63, P < 0.01). HBV DNA positive rate in HBeAg positive group was significantly higher than HbeAg negative group. In HbeAg positive group, viral load and inflammation grading integral were negatively correlated (P < 0.05). In HbeAg negative group, viral load and inflammation grading integral were positively correlated (P < 0.05); Viral load and fibrosis staging integral were also positively correlated (P < 0.01).