9) 2,279 (24.8) 332 (21.7) 843 (22.6) 5 (11.4) 1,182 (22.2) Treating specialty General learn more medicine 8,351 (57.5) 5,375 (58.5) 654 (42.8) 2,307 (61.8) 12 (27.3) 2,976 (56.0) Intensive care unit 3,758 (25.9) 2,167 (23.6) 654 (42.8) 910 (24.4) 22 (50.0) 1,591 (29.9) Surgery 739 (5.1) 501 (5.4) 82 (5.4) 151 (4.0) <5 238 (4.5) CUDC-907 research buy Other 1,663 (11.5) 1,150 (12.5) 139 (9.1) 367 (9.8) 6 (13.6) 238 (4.5) Pneumococcal immunization 1 year prior to infection 1,274 (8.8) 831 (9.0) 120 (7.8)
318 (8.5) <5 443 (8.3) 5 years prior to infection 4,386 (30.2) 2,855 (31.1) 435 (28.4) 1,084 (29.0) 9 (20.5) 1,531 (28.8) 10 years prior to infection 5,274 (36.3) 3,441 (37.4) 513 (33.6) 1,305 (34.9) 11 (25.0) 1,833 (34.5) History of multiple pneumococcal infectionse 5,279 (36.4) 3,277
(35.6) 566 (37.0) 1,421 (38.0) 13 (29.5) 2,002 (37.6) Infection diagnosis previous year Pneumoniaf 4,244 (29.2) 3,046 (33.1) 433 (28.3) 759 (20.3) <5 1,198 (22.5) Bacteremiaf 551 (3.8) 160 (1.7) 137 (9.0) 250 (6.7) <5 391 (7.4) Streptococcus species infectiong 1,726 (11.9) 1,207 (13.1) 188 (12.3) 326 (8.7) <5 519 (9.8) Charlson comorbidity index, median (IQR) 1 (0–3) 1 (0–2) 1 (0–3) 2 (0–3) 0 (0–2) 2 (0–3) Comorbid conditions Heart failure 2,118 (14.6) 1,269 (13.8) 250 (16.4) 595 (15.9) <5 849 (16.0) Chronic respiratory disease 5,827 (40.2) 4,034 CP-690550 molecular weight (43.9) 559 (36.6) 1,233 (33) <5 1,793 (33.7) Diabetes 2,344 (16.2) 1,287 (14) 243 (15.9)
806 (21.6) 6 (13.6) 1,057 (19.9) Diabetes with complications 328 (2.3) 192 (2.1) 24 (1.6) 112 (3) – 136 (2.6) Tobacco use 1,856 (12.8) 1,283 (14.0) 149 (9.7) 422 (11.3) <5 573 (10.8) Alcohol abuse 1,307 (9.0) 726 (7.9) 175 (11.4) 397 (10.6) 7 (15.9) 581 (10.9) Mild liver disease 851 (5.9) 318 (3.5) 124 (8.1) 406 (10.9) <5 533 (10.0) HIV/AIDS 246 (1.7) 100 (1.1) 30 (2.0) 113 (3.0) <5 146 (2.7) Chronic renal disease 1,233 (8.5) 570 (6.2) 169 (11.1) 493 (13.2) – 663 (12.5) Dialysis 397 (2.7) 135 (1.5) 103 (6.7) 157 (4.2) <5 262 (4.9) Transplant Nintedanib (BIBF 1120) 79 (0.5) 32 (0.3) 10 (0.7) 36 (1.0) <5 47 (0.9) Immunity disorders 26 (0.2) 11 (0.1) 5 (0.3) 10 (0.3) – 15 (0.3) Cancer 2,355 (16.2) 1,308 (14.2) 272 (17.8) 768 (20.6) 7 (15.9) 1,047 (19.7) Metastatic cancer 572 (3.9) 312 (3.4) 69 (4.5) 190 (5.1) <5 260 (4.9) Length of stay (days), median (IQR) 6 (3–13) 6 (3–12) 12 (6–25) 6 (4–12) 11 (6.5–15.5) 7 (4–15) Inpatient mortality 1,972 (13.6) 872 (9.5) 445 (29.1) 649 (17.4) <5 1,100 (20.7) 30-day mortality 2,596 (17.9) 1,301 (14.2) 441 (28.8) 848 (22.7) 5 (11.4) 1,295 (24.4) Data are no.